{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:53Z","timestamp":1787596133347,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Limited evidence is available on the impact of direct\u2010acting antiviral (DAA) therapy on immune activation biomarkers in individuals coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). This study aimed to characterize longitudinal changes in soluble intercellular adhesion molecule\u20101 (sICAM\u20101), soluble \u03b22\u2010microglobulin (s\u03b22M), and soluble CD14 (sCD14), following DAA treatment in an HIV\/HCV\u2010coinfected cohort in Indonesia. A prospective study was conducted involving 132 HIV\/HCV\u2010coinfected individuals treated with sofosbuvir\/daclatasvir for 12 or 24 weeks. Plasma samples were collected at baseline and 12 weeks post\u2010DAA therapy. Levels of sICAM\u20101, s\u03b22M, and sCD14 were quantified using enzyme\u2010linked immunosorbent assay (ELISA). Linear regression analyses were performed to identify predictors of biomarker changes. A sustained virological response was achieved in 96.2% of coinfected participants. At baseline, the HIV\/HCV\u2010coinfected group exhibited significantly higher levels of sICAM\u20101 and sCD14 compared to levels found in HIV monoinfection. At 12 weeks post\u2010treatment, significant reductions in sICAM\u20101 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0002) and s\u03b22M levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0002) were observed, irrespective of the baseline liver fibrosis stage. No significant change was noted in sCD14 levels. Notably, sICAM\u20101 levels post\u2010treatment remained elevated compared to those in HIV monoinfection. Lower baseline serum albumin was an independent predictor of s\u03b22M reduction. DAA therapy was associated with significant reductions in sICAM\u20101 and s\u03b22M levels among HIV\/HCV\u2010coinfected individuals, irrespective of liver fibrosis stage. These findings highlight the immunomodulatory benefits of DAA therapy across different stages of liver disease in the Indonesian population.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70627","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:31:55Z","timestamp":1759793515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Changes in Immune Biomarkers Following Direct\u2010Acting Antiviral Therapy in HIV\/HCV\u2010Coinfected Individuals in Indonesia"],"prefix":"10.1002","volume":"97","author":[{"given":"Evy","family":"Yunihastuti","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia Jakarta Indonesia"},{"name":"HIV Integrated Clinic Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-1538","authenticated-orcid":false,"given":"Youdiil","family":"Ophinni","sequence":"additional","affiliation":[{"name":"The Hakubi Center for Advanced Research Kyoto University Kyoto Japan"},{"name":"Department of Environmental Coexistence, Center for Southeast Asian Studies Kyoto University Kyoto Japan"},{"name":"Division of Clinical Virology, Center for Infectious Diseases, Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam","family":"Adli","sequence":"additional","affiliation":[{"name":"HIV Integrated Clinic Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Environmental Coexistence, Center for Southeast Asian Studies Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvina","family":"Widhani","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia Jakarta Indonesia"},{"name":"HIV Integrated Clinic Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri","family":"Sanityoso","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino Alvani","family":"Gani","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.004"},{"key":"e_1_2_13_4_1","first-page":"1473","article-title":"HIV\u2010HCV Co\u2010Infection: Epidemiology, Pathogenesis and Therapeutic Implications","volume":"16","author":"Andreoni M.","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_13_5_1","unstructured":"Ministry of Health of the Republic of Indonesia. 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