{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T21:55:01Z","timestamp":1769896501849,"version":"3.49.0"},"reference-count":80,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Viruses in the genus\n                    <jats:italic>Orthoflavivirus<\/jats:italic>\n                    are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad\u2010spectrum treatments and preventive measures for these viral infections in humans. One of the most promising targets for developing treatments or vaccines is glycan molecules, found on both viral and host proteins, which are essential during the infectious cycle. This review examines various antiviral and immunization approaches focused on glycoproteins to fight orthoflavivirus infections.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70637","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:19:26Z","timestamp":1760008766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Sweet Aspects of\n                    <i>Orthoflavivirus<\/i>\n                    Treatment Design and Vaccine Development"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6882-4765","authenticated-orcid":false,"given":"Ana C.","family":"Alcal\u00e1","sequence":"first","affiliation":[{"name":"Department of Infectomics and Molecular Pathogenesis Center for Research and Advanced Studies (Cinvestav) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-2572","authenticated-orcid":false,"given":"Michelle","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Molecular y Bioprocesos Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico Cuernavaca M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-7681","authenticated-orcid":false,"given":"Juan E.","family":"Ludert","sequence":"additional","affiliation":[{"name":"Department of Infectomics and Molecular Pathogenesis Center for Research and Advanced Studies (Cinvestav) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-024-01048-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011681"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01611-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.1.564-572.2000"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1252"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13262-13274.2005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01900-09"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.10.112"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00157-12"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.11.020"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.036"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247749"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15051102"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.02.022"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18631"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.094"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.03.003"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00275-18"},{"key":"e_1_2_5_20_1","volume-title":"Chapter 29 Principles of Glycan Recognition. 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