{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:19:35Z","timestamp":1789507175772,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Varicella vaccination has significantly reduced varicella incidence, but raised concerns regarding the potential reactivation of herpes zoster (HZ) reactivation. This study evaluated the epidemiology of HZ in young patients and the causative varicella\u2010zoster virus (VZV) genotype. This prospective study collected data through the Healthcare Big Data Center of Yichang, China, including patients with HZ aged \u2264\u200920 years. Clinical characteristics and economic burden were assessed using questionnaires, and virological analyses of vesicular fluid and throat\u2010swab samples were performed to identify the VZV genotype. Kaplan\u2013Meier plots and regression models were applied to assess the disease burden. Forty\u2010six patients with HZ were identified (median age: 15.2 years, male\u2010to\u2010female ratio: 1.3). Genotyping confirmed revealed only wild\u2010type VZV in all cases without evidence of vaccine strain reactivation. Vesicular eruptions predominantly affected the thoracic region, with a mean disease course of 21.2 days; only five patients reported postherpetic neuralgia. No significant differences were observed between vaccinated and unvaccinated groups in terms of clinical outcomes or economic burden. The incidence of HZ in adolescents is low and generally mild. Varicella vaccination appears safe for up to at least 10 years postvaccination without evidence of vaccine strain\u2010mediated HZ reactivation.<\/jats:p>","DOI":"10.1002\/jmv.70643","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:56:14Z","timestamp":1760406974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology and Clinical Profile of Herpes Zoster in the Varicella Vaccine Era: A Case Series Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-4958","authenticated-orcid":false,"given":"Binshan","family":"Jiang","sequence":"first","affiliation":[{"name":"Public Health Emergency Management Innovation Center, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College) Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Hu","sequence":"additional","affiliation":[{"name":"Office of Epidemiology Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Cui","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"You","sequence":"additional","affiliation":[{"name":"Office of Epidemiology Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Xu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzhao","family":"Feng","sequence":"additional","affiliation":[{"name":"Public Health Emergency Management Innovation Center, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College) Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Hainan Center for Disease Control and Prevention  Hainan China"},{"name":"Hainan Academy of Preventive Medicine  Hainan China"},{"name":"Hainan Medical University  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2014.04.28.33.52.e8249"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/82_2009_3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70268-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1305"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28329-1"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"95","article-title":"Varicella\u2010Zoster Virus Infection: Natural History, Clinical Manifestations, Immunity and Current and Future Vaccination Strategies","volume":"41","author":"Freer G.","year":"2018","journal-title":"New 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