{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T21:54:40Z","timestamp":1769896480964,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The 2\u2032,5\u2032\u2010oligoadenylate synthetase (OAS)\u2010ribonuclease L (RNase L) system, induced by type I interferons, defends against RNA viruses. Inborn errors in this pathway may trigger inflammatory cytokines, contributing to SARS\u2010CoV\u20102\u2010related multisystem inflammatory syndrome in children (MIS\u2010C). This study examined circulating RNase L, cytokines, and chemokines in MIS\u2010C. A prospective multicenter cohort study conducted in Taiwan from 2022 to 2023 recruited children with MIS\u2010C, age\u2010 and gender\u2010matched children with mild COVID\u201019, and healthy controls. Plasma cytokines, chemokines, and RNase L levels were measured, and clinical severity was analyzed. Among 108 children (63 boys and 45 girls), cytokine and chemokine levels positively correlated with disease severity, while RNase L levels were negatively correlated. IL\u201017A\u2009&gt;\u20098.9\u2009pg\/mL and RNase L\u2009&lt;\u20093.6\u2009\u03bcg\/mL differentiated MIS\u2010C from mild COVID\u201019 (83% sensitivity, 94% specificity). CXCL9\/MIG\u2009&gt;\u20091129\u2009pg\/mL and RNase L\u2009&lt;\u20092.8\u2009\u03bcg\/mL distinguished MIS\u2010C patients with and without shock (79% sensitivity, 91% specificity). Findings reveal a systemic inflammatory signature in MIS\u2010C, with pro\u2010inflammatory, T cell activation, regulatory, and anti\u2010inflammatory responses. Elevated IL\u201017A and CXCL9\/MIG and decreased RNase L levels serve as sensitive biomarkers of MIS\u2010C and disease severity.<\/jats:p>","DOI":"10.1002\/jmv.70650","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:45:51Z","timestamp":1761122751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of RNase L, Cytokines, and Chemokines With Severity of Multisystem Inflammatory Syndrome in Children"],"prefix":"10.1002","volume":"97","author":[{"given":"Ting\u2010Yu","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei 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