{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:53Z","timestamp":1791945953403,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants, resulting in millions of cases and hundreds of thousands of deaths worldwide every year. Nirsevimab, a long\u2010acting monoclonal antibody approved in 2023, has 75%\u201390% protection against RSV\u2010related admissions. This study evaluated the effectiveness of nirsevimab in preventing RSV\u2010hospitalization among infants in southern Italy during 2024\u20132025 season. Active surveillance was conducted in all hospitals in the Foggia district. Infants born between January 2024 and March 2025 who were hospitalized with lower respiratory tract infections from October 2024 to April 2025 were tested for RSV. Information on immunoprophylaxis was provided by the Regional Immunization Information System. The effectiveness of nirsevimab was estimated using the screening method, a test\u2010negative case\u2010control design and a cohort study approach. Of the 4820 eligible infants, 2635 (54.7%) were immunized. Of the 256 infants admitted with lower respiratory tract infections, 82 tested positives for RSV; of these, 13 had received immunoprophylaxis. The effectiveness was estimated to be 84.4% (95% CI: 71.7\u201391.4%) using the screening method, 72.5% (42.1%\u201387.0%) using the test\u2010negative design, and 81.6% (66.4\u201390.0) using the cohort approach. As in previous study, these findings showed than nirsevimab provide substantial protection against RSV\u2010related hospitalization.<\/jats:p>","DOI":"10.1002\/jmv.70662","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:18:57Z","timestamp":1761833937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Real\u2010World Effectiveness of Nirsevimab in Preventing RSV Hospitalizations: Evidence of Protection in Southern Italian Infants, 2024\u20132025"],"prefix":"10.1002","volume":"97","author":[{"given":"Francesca","family":"Fortunato","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Foggia Foggia Italy"},{"name":"Hygiene Unit, Policlinico Foggia Hospital Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Prato","sequence":"additional","affiliation":[{"name":"Department of Medical and 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Calvo","sequence":"additional","affiliation":[{"name":"Microbiology and virology Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, San Giovanni Rotondo Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Neonatology and Intensive Care Unit, Policlinico Foggia Hospital Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Lopalco","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Salento Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-3167","authenticated-orcid":false,"given":"Domenico","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Foggia 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