{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:47Z","timestamp":1791945947585,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Universal prophylaxis or a preemptive strategy with valganciclovir (VGCV) is recommended for prevention of cytomegalovirus (CMV) infections after kidney transplantation. We combined both strategies during the first 3 months post\u2010transplantation. The objectives were to define the incidence of CMV DNAemia and identify the associated factors during universal prophylaxis in a retrospective monocentric case\u2010control study. Cases presenting CMV DNAemia during the first 3 months post\u2010transplantation were matched to four controls each regarding sex, age, donor and recipient CMV serostatus, and induction treatment. We collected the rates of visits with VGCV underdosing, comparing the adjusted daily dosage to the kidney function and the received daily dosage. Despite prophylaxis, the incidence of CMV DNAemia was 5.1% between 2017 and 2020 in 300 patients. Rates of visits with VGCV underdosing during follow\u2010up were significantly higher in the cases group than in the controls group. In the cases group, the rate was higher when using estimated creatinine clearance rather than estimated glomerular filtration rate. VGCV underdosing was the only factor associated with CMV DNAemia in the multivariate analysis (OR: 1.04 95% CI: 1.011\u20131.061,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), regardless of the formula used to estimate kidney function. Resistance to GCV was observed in 4 out of 15 cases, two of which had VGCV underdosing. In our study, CMV DNAemia was associated with VGCV underdosing that could be related to the absence of systematic adjustment during post\u2010transplantation follow\u2010up or to the use of inadequate kidney function assessment formulas to adjust VGCV dosages.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70666","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:09:42Z","timestamp":1761311382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Valganciclovir Underdosing Is Associated With Cytomegalovirus DNAemia During Universal Prophylaxis: A Real\u2010Life Case Control Retrospective Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7775-5157","authenticated-orcid":false,"given":"Pierre\u2010Antonin","family":"Rigon","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"},{"name":"Aix\u2010Marseille Universite\u0301 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Solignac","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"},{"name":"Aix\u2010Marseille Universite\u0301 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Zandotti","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Marseille, Service de Virologie Aigu\u00eb et Tropicale Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Gully","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brunet","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"},{"name":"Aix\u2010Marseille Universite\u0301 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[{"name":"CEReSS\/UR 3279\u2014Health Services and Quality of Life Research Aix Marseille University Marseille France"},{"name":"Methodological Support Unit for Clinical and Epidemiological Research University Hospital of Marseille Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Legris","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Moal","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010Ho\u0302pitaux de Marseille, Ho\u0302pital Conception, Centre de Ne\u0301phrologie et Transplantation Re\u0301nale Marseille France"},{"name":"Aix\u2010Marseille Universite\u0301 Marseille 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