{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:19Z","timestamp":1791945979843,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This descriptive observational study based on post\u2010marketing surveillance data evaluates adverse events following immunization (AEFI) associated with the TAK\u2010003 (Qdenga\u00ae) vaccine. Conducted in Dourados, Brazil, between January and November 2024, the study aimed to assess the frequency, nature, and severity of AEFI to inform public health strategies. Secondary data were obtained from the e\u2010SUS Notifica system, including demographic information, vaccination dates, and details of AEFI, which encompassed immunization errors and adverse events. These adverse events were classified by severity, type, and temporal distribution. Statistical analysis included incidence rates, temporal trends, and correlation analyses using SPSS software. Among 124,483 administered doses, 88 AEFI were reported, yielding an incidence rate of 70.69 per 100.000 doses. Most events (49.00 per 100.000 doses) were Nonserious, including headache, fever, and rash. Serious AEFI were rare (6.42 per 100.000 doses), with two cases of grade 1 anaphylaxis and two Guillain\u2010Barr\u00e9 syndrome (GBS) cases. Women (71.01%) and individuals aged 30\u201339 years (82.06 per 100.000 doses) were the most affected. Twenty seven Immunization errors were reported for 30.68% of AEFI, often linked to gaps in training. TAK\u2010003 demonstrated a favorable safety profile, consistent with clinical trial findings, characterized predominantly by mild, self\u2010limiting adverse events, with serious adverse events occurring infrequently. These findings underscore the importance of enhanced training protocols, robust surveillance systems, and timely reporting to optimize vaccine safety and maintain public trust.<\/jats:p>","DOI":"10.1002\/jmv.70674","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:56:00Z","timestamp":1761663360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adverse Events and Immunization Errors Following a Mass Immunization Campaignwith TAK\u2010003 in Dourados, Brazil:\n                    <i>A Post\u2010Marketing Safety Surveillance Analysis<\/i>"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4694-9508","authenticated-orcid":false,"given":"Luana Clemm Kuhnen","family":"Anschau","sequence":"first","affiliation":[{"name":"Post Graduate Program in Health Sciences Federal University of Grande Dourados Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4304-546X","authenticated-orcid":false,"given":"Amanda Maria Miguel","family":"Bortuluzi","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Health Sciences Federal University of Grande Dourados Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-6378","authenticated-orcid":false,"given":"Andrea da Silva","family":"Santos","sequence":"additional","affiliation":[{"name":"Health Sciences Faculty Federal University of Grande Dourados Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanildo de Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Municipal Health Department of Dourados Municipal Prefecture of Dourados Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra de Souza","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Municipal Health Department of Dourados Municipal Prefecture of Dourados Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indianara Ramires","family":"Machado","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato de \u00c1vila","family":"Kfouri","sequence":"additional","affiliation":[{"name":"Department of Immunizations Brazilian Society of Pediatrics S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Palazzi","family":"S\u00e1fadi","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-8011","authenticated-orcid":false,"given":"Roberto Dias de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Health Sciences Federal University of Grande Dourados Dourados MS Brazil"},{"name":"Nursing Course State University of Mato Grosso do Sul Dourados MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-6825","authenticated-orcid":false,"given":"Julio","family":"Croda","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul Campo Grande MS Brazil"},{"name":"Oswaldo Cruz Foundation \u2010 Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.glohj.2019.06.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0476-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00317"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2460"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2020-0572"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2023.102598"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac418"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab864"},{"key":"e_1_2_10_10_1","unstructured":"TAKEDA. 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