{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:46Z","timestamp":1791945946305,"version":"4.3.4"},"reference-count":118,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Kaposi's sarcoma (KS) is a multicentric, polyclonal malignancy linked to Kaposi's sarcoma\u2010associated herpesvirus (KSHV) infection. While significant advances have been made in understanding KSHV virology and the clinical characteristics of KS, the precise mechanisms of pathogenesis and cellular origins remain elusive. This review integrates clinical observations with the latest cutting\u2010edge research to explore the nature and potential cellular precursors of KS. Multiple cell types have been proposed as potential KS oncogenic progenitors, including endothelial cells, mesenchymal stem cells (MSCs), and circulating endothelial progenitor cells (EPCs). KS progenitor cells are thought to be recruited to sites of inflammatory angio\u2010hyperplasia, where they may undergo KSHV\u2010mediated transformation. Intriguingly, KSHV has been shown to modulate both endothelial\u2010to\u2010mesenchymal transition (EndMT) and mesenchymal\u2010to\u2010endothelial transition (MEndT). By elucidating the mechanisms underlying KSHV\u2010mediated cellular plasticity and the synergistic effects of inflammatory angio\u2010hyperplasia and viral lytic reactivation in driving malignant transformation, we aim to deepen our understanding of KSHV\u2010driven oncogenesis. This review highlights promising avenues for future research, including the potential role of KSHV in other mesenchymal\u2010derived sarcomas, such as osteosarcoma. Ultimately, unraveling the complex interactions between KSHV, host cells, and the tumor microenvironment may pave the way for novel therapeutic strategies for patients with KS and related malignancies.<\/jats:p>","DOI":"10.1002\/jmv.70675","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:01:43Z","timestamp":1762279303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Origin of Kaposi's Sarcoma and Other KSHV\u2010Associated Sarcomas"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-1955","authenticated-orcid":false,"given":"Yan","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ding","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, and Medical Research Institute, Guangdong Provincial People's Hospital, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321801"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.7.2708.2708"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ996"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"Q.Chen J.Chen Y.Li et al. \u201cKaposi's Sarcoma Herpesvirus Is Associated With Osteosarcoma in Xinjiang Populations \u201dProceedings of the National Academy of Sciences118 no.10(2021) https:\/\/doi.org\/10.1073\/pnas.2016653118.","DOI":"10.1073\/pnas.2016653118"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2768"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju503"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30125-X"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001567"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40567"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm045"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8257"},{"issue":"8","key":"e_1_2_11_15_1","first-page":"825","article-title":"Cytogenetic Study of Kaposi's Sarcoma Associated With Acquired Immunodeficiency Syndrome","volume":"112","author":"Saikevych I. 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