{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:03Z","timestamp":1791945963561,"version":"4.3.4"},"reference-count":7,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The recently mutated Omicron variant of SARS\u2010CoV\u20102 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from convalescent individuals (n\u2009=\u2009308) with breakthrough infections who had received different immunization regimens and from healthy people over the subsequent year after epidemic control ceased in China on 7 December 2022. We assessed the susceptibility of the serum to the prototype, Omicron BA.5.2, Omicron XBB.1.5, and Omicron JN.1.5 subvariants at 3\u2010, 5\u2010, 8\u2010 and 11\u2010months postinfection. The results demonstrated that two booster immunizations did not enhance the immune response, indicating that breakthrough Omicron infection does not effectively increase immunity against other Omicron subvariants. Rather, the breakthrough infection might even weaken the immune response to Omicron subvariants due to antigenic imprinting, highlighting the necessity of optimizing vaccination strategies and adjusting epidemic prevention measures to the situation.<\/jats:p>","DOI":"10.1002\/jmv.70681","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:46:27Z","timestamp":1762868787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS\u2010CoV\u20102 Omicron Variants Following Breakthrough Infections"],"prefix":"10.1002","volume":"97","author":[{"given":"Jianhua","family":"Li","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University Hangzhou P. R. China"},{"name":"Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College Zhejiang Shuren University Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College Zhejiang Shuren University Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Mao","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Public Health Detection and Pathogenesis Research, Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-0991","authenticated-orcid":false,"given":"Keda","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College Zhejiang Shuren University Hangzhou P. R. 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