{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:49Z","timestamp":1791945949529,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis C virus (HCV) infection remains prevalent in multiply transfused patients, even in the era of rigorous donor screening. While the hepatic effects of HCV have been well documented, its influence on malignancy outcomes and mortality remains underexplored. This study evaluated the incidence of HCV among pediatric acute lymphoblastic leukemia (ALL) patients and its impact on treatment interruption, overall survival (OS), and relapse\u2010free survival. A retrospective analysis of medical records was conducted for 166 ALL patients treated between January 2016 and December 2021 at the Pediatric Oncology and Hematological Malignancies Department, South Egypt Cancer Institute. HCV\u2010Serology status of all patients was regularly followed up through December 2023. Among the 166 patients, 65 (39.2%) were HCV\u2010positive. HCV\u2010positive Patients experienced a significantly higher relapse risk \u22126.7\u2010times greater\u2010than HCV\u2010negative peers (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No statistically significant difference was observed in OS between the groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.812). The high incidence of HCV among pediatric ALL patients may represent a risk factor for relapse. Early detection and appropriate management of HCV could enhance patient prognosis and warrant further attention in clinical protocols.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70683","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:27:42Z","timestamp":1762345662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cExploring Hepatitis C as a Relapse Risk Factor in Pediatric Acute Lymphoblastic Leukemia: A Study From a Resource\u2010Limited Egyptian Setting\u201d"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-9119","authenticated-orcid":false,"given":"Lamiaa Fadel","family":"Alkilany","sequence":"first","affiliation":[{"name":"Virology and Immunology Unit, Cancer Biology Department South Egypt Cancer Institute, Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-6166","authenticated-orcid":false,"given":"Shaza Fadel","family":"Alkilany","sequence":"additional","affiliation":[{"name":"Public Health and Community Medicine Department Faculty of Medicine, Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Gaber","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, South Egypt Cancer Institute Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Farrag","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematological Malignancies Department South Egypt Cancer Institute, Assiut University Assiut Egypt"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics Children\u2032s Hospital of Central Switzerland Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Mahmoud","family":"Osman","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematological Malignancies Department South Egypt Cancer Institute, Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2022.85"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2020.93891"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3138\/canlivj.2019-0009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i16.2247"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0094-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.031"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21403"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2145"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460405"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1616"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2018.1483986"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.18"},{"issue":"12","key":"e_1_2_10_14_1","first-page":"5477","article-title":"Clinical Significance of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia and Its Relationship to Other Prognostic Factors: A Children's Oncology Group Study","volume":"111","author":"Borowitz M. 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