{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:49Z","timestamp":1791945949481,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To develop new tools integrating host immune response and viral activity to predict Peg\u2010IFN\u03b1 therapy efficiency in nucleos(t)ide analogs (NUCs)\u2010treated chronic hepatitis B (CHB) patients. This\n                    <jats:italic>post\u2010hoc<\/jats:italic>\n                    study analyzed data from 758 NUCs\u2010experienced, HBeAg\u2010negative CHB patients with baseline HBsAg &lt;\u20091500 IU\/mL and undetectable serum HBV DNA who completed 48 weeks of Peg\u2010IFN\u03b1 add\u2010on therapy in a prospective study. Clinical and biochemical data were collected every 12 weeks and evaluated for their predictive value of HBsAg seroclearance and seroconversion. Age, qHBsAg, and ALT levels at Week 12 were associated with both HBsAg seroclearance and seroconversion. The ASAP\u201012 score (ALT\/[qHBsAg \u00d7 Age] at Week 12), demonstrated strong discrimination for both endpoints (AUROCs: 0.802 [cut\u2010off 0.07] and 0.787 [cut\u2010off 0.12], respectively;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Patients with scores above the respective cut\u2010offs had significantly higher cumulative probabilities of HBsAg seroclearance (63.4% vs. 17.8%, Log\u2010rank test\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and seroconversion (47.3% vs. 11.0%, Log\u2010rank test\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Higher ASAP\u201012 scores (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.206,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) independently correlated with elevated Week 48 HBsAb levels. The ASAP\u201012 score may serve as a useful tool to predict both HBsAg seroclearance and seroconversion at Week 48 of Peg\u2010IFN\u03b1 add\u2010on therapy in NUCs\u2010experienced CHB patients, supporting individualized therapeutic decisions.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70684","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:58:11Z","timestamp":1761832691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ASAP\u201012 Score Predicts HBsAg Seroclearance and Seroconversion in Chronic Hepatitis B Patients Receiving Peg\u2010IFN\u03b1 Add\u2010On Therapy"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-9283","authenticated-orcid":false,"given":"Jiayi","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Infectious Diseases West China Hospital of Sichuan University Chengdu 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