{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:16Z","timestamp":1791945976626,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis B virus (HBV) exhibits significant genetic diversity affecting clinical outcomes and interventions. Utilizing 4326 HBsAg\u2010positive samples from China's 2020 national serosurvey (91\u2009896 participants), we successfully sequenced S genes from 3311 specimens. Genotypes\/subgenotypes were determined through maximum likelihood phylogeny; serotypes followed Purdy's method. Demographic, serological, and regional associations were analyzed by chi\u2010square tests. Five HBV genotypes were identified: B (63.91%), C (22.80%), CD (10.48%), D (2.45%) and I (0.36%), plus 15 subgenotypes (B2 dominant, 61.73%). Four serotypes emerged: adw (60.65%), adr (24.37%), ayw (14.53%), and ayr (0.33%), with 10 subserotypes (adw2 dominant, 58.86%). Genotype B predominated East\/Central\/South China; C prevailed in North\/Northeast China. Southwest\/Northwest China showed co\u2010circulation, with CD predominant in Southwest and D in Northwest China. B2 comprised 96.60% of genotype B; adw2 represented 97.06% of adw. Genotype distribution showed significant regional variation and strong associations with gender, age, ethnicity, serological profile, viral load, and serotype (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). HBV in China exhibits marked genetic heterogeneity characterized by distinct regional and population patterns. These findings underscore the necessity for tailored prevention strategies and optimized diagnostics\/vaccines to address region\u2010specific HBV diversity.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70685","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:19:15Z","timestamp":1762201155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Profiles of Hepatitis B Virus Genotypes Among 1\u201369\u2010year\u2010olds in the Mainland of China"],"prefix":"10.1002","volume":"97","author":[{"given":"Qiudong","family":"Su","sequence":"first","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Daxing District Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Shen","sequence":"additional","affiliation":[{"name":"The Testing Facility Beijing ShouYan Lab Service Co. Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2722-2"},{"key":"e_1_2_10_3_1","article-title":"New Progress in HBV Control and the Cascade of Health Care for People Living With HBV in China: Evidence From the Fourth National Serological Survey, 2020","volume":"51","author":"Zheng H.","year":"2024","journal-title":"Lancet Reg Health West Pac"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94286-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11071011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2023.102180"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i21.6684"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.09.083"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027941"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268821002326"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313269"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.127128"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"759","article-title":"Epidemiological Distribution of Genotypes and Sub\u2010Genotypes of Hepatitis B Virus in 15 Ethnic Groups in China","volume":"44","author":"Guo X. 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