{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:42Z","timestamp":1791945942921,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rotavirus Group A (RVA) infection is a significant cause of acute gastroenteritis in children. This study aimed to characterize RVA in Chiang Rai, Thailand, from 2022 to 2023. A total of 274 fecal samples were tested for RVA by RT\u2010PCR. RVA was detected in 9.9% (27\/274). The predominant RVA genotype was typical human G3P[8] (26\/27, 96.3%), followed by G4P[6] (1\/27, 3.7%). The highest infection rate was observed in children under 5 years of age (25\/27, 92.6%). RVA was widespread with a single peak extending from winter to summer. Phylogenetic analysis revealed two lineages of G3P[8] strains circulating in Thailand: the typical human G3P[8] and the equine\u2010like G3P[8]. The G3P[8] strains in this study had aspartic acid (D) at position 221, whereas previously reported G3P[8] strains had alanine (A). These G3P[8] strains had a Wa\u2010like backbone: G3\u2010P[8]\u2010I1\u2010R1\u2010C1\u2010M1\u2010A1\u2010N1\u2010T1\u2010E1\u2010H1 constellation. G3P[8] strains also carried some amino acid differences in the antigenic epitopes comparted to vaccine strains. Homology models of the VP7 and VP8* proteins confirmed that these differences were on the surface\u2010exposed region of the outer capsid structure. It is of interest whether these typical human G3P[8] strains will emerge in the future and replace other genotypes.<\/jats:p>","DOI":"10.1002\/jmv.70691","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:59:18Z","timestamp":1762513158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Prevalence of Typical Human Wa\u2010Like G3P[8] Rotavirus Strains in Children Hospitalized With Acute Gastroenteritis in Thailand, 2022\u20132023"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8826-3598","authenticated-orcid":false,"given":"Wisoot","family":"Chan\u2010It","sequence":"first","affiliation":[{"name":"Microbiology Program, Faculty of Science and Technology Pibulsongkram Rajabhat University Phitsanulok 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