{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:30:13Z","timestamp":1783924213911,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oral polio vaccine (OPV) from attenuated Sabin strains widely used for poliomyelitis prevention and eradication along with undeniable advantages has significant disadvantages, one of which is the ability to cause cases of vaccine\u2010associated paralytic poliomyelitis (VAPP). Inactivated poliovirus vaccine (IPV) introduction into the national immunization schedules of countries that continue to use OPV allows effective prevention of VAPP cases and simultaneously forms immunity to PV type 2. The present study presents an example of VAPP development in a child with Bruton's disease, born by in vitro fertilization, vaccinated with four IPV doses followed by one bOPV dose, and paralysis onset 52 days bOPV vaccination. Despite objective clinical, laboratory and instrumental signs of anterior corneal myelitis, the isolation of Sabin\u2010like poliovirus, and contradictory results of serological investigation, diagnostics caused significant difficulties for the treating physicians. The case was associated with a recombinant poliovirus of vaccine Sabin strains types 3 and 1 with a recombination point in 2C\u2010encoding genome region, containing known neurovirulence reverse mutations and some unique ones. The introduction of IPV doses for primary immunization increases the safety of immunization against polio; however, while OPV is in use there is still a VAPP threat for immunocompromised children and unvaccinated contacts.<\/jats:p>","DOI":"10.1002\/jmv.70704","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:31:32Z","timestamp":1764073892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Flaccid Paralysis in a Vaccinated Child With Primary Immunodeficiency: Difficulties With Diagnostics of Vaccine\u2010Associated Paralytic Poliomyelitis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-3631","authenticated-orcid":false,"given":"Armen K.","family":"Shakaryan","sequence":"first","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune\u2010and\u2010Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI Chumakov FSC R&amp;D IBP RAS [Institute of poliomyelitis]) Moscow Russia"},{"name":"Federal State Autonomous Educational Institution of Higher Education \u201cN.I. Pirogov Russian National Research Medical University\u201d of the Ministry of Health of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4895-8712","authenticated-orcid":false,"given":"Yulia M.","family":"Mikhailova","sequence":"additional","affiliation":[{"name":"Federal Budgetary Health Institution \u201cFederal Center of Hygiene and Epidemiology\u201d of the Federal Office for Inspectorate in the Field of Customers and Human Well\u2010Being Protection Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7092-0836","authenticated-orcid":false,"given":"Alina V.","family":"Chirova","sequence":"additional","affiliation":[{"name":"Federal Budgetary Health Institution \u201cFederal Center of Hygiene and Epidemiology\u201d of the Federal Office for Inspectorate in the Field of Customers and Human Well\u2010Being Protection Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-5612","authenticated-orcid":false,"given":"Evgeniya A.","family":"Cherepanova","sequence":"additional","affiliation":[{"name":"Federal Budgetary Health Institution \u201cFederal Center of Hygiene and Epidemiology\u201d of the Federal Office for Inspectorate in the Field of Customers and Human Well\u2010Being Protection Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2262","authenticated-orcid":false,"given":"Olga Y.","family":"Baikova","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune\u2010and\u2010Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI Chumakov FSC R&amp;D IBP RAS [Institute of poliomyelitis]) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7211-0076","authenticated-orcid":false,"given":"Elizaveta V.","family":"Yakovchuk","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune\u2010and\u2010Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI Chumakov FSC R&amp;D IBP RAS [Institute of poliomyelitis]) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-0958","authenticated-orcid":false,"given":"Evgenia V.","family":"Karpova","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune\u2010and\u2010Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI Chumakov FSC R&amp;D IBP RAS [Institute of poliomyelitis]) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-7136","authenticated-orcid":false,"given":"Aleksander P.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune\u2010and\u2010Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI Chumakov FSC R&amp;D IBP RAS [Institute of poliomyelitis]) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Skryabina","sequence":"additional","affiliation":[{"name":"Federal Budgetary Health Institution \u201cCenter for Hygiene and Epidemiology in the Sverdlovsk Region\u201d Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7857-6810","authenticated-orcid":false,"given":"Tatiana E.","family":"Snitkovskaya","sequence":"additional","affiliation":[{"name":"Federal Budgetary Health Institution \u201cCenter for Hygiene and Epidemiology in the Sverdlovsk Region\u201d Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-3124","authenticated-orcid":false,"given":"Artyom A.","family":"Basov","sequence":"additional","affiliation":[{"name":"Federal Budgetary Institution of Science \u201cG.N. 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