{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:03:44Z","timestamp":1771315424007,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Identify specific Human Papilloma Virus (HPV) genomic status by HPV capture technique coupled with next\u2010generation sequencing (NGS) in patients with early cervical cancer (ECC) regarding 2018 FIGO stages and correlate these statuses with prognosis. HPV sequencing by Capture technique coupled with NGS was performed on 34 tumors samples of ECC patients without histologically sentinel lymph node (SLN) metastasis in a retrospective study. NGS data were analyzed in our in\u2010house VIROCAPT2 pipeline to determine precise HPV genomic status such as the complete sequence of HPV genome, its integration or not in host genome and correlate this viral identity card with patient's clinical prognosis. As expected, HPV16 remains the most common genotype (60%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921\/35) in ECC. HPV integration was identified in 40% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914\/35) of samples. We found that in ECC, integration events were related with HPV genotype (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005). Among the 40% of integrated HPV, 8 were found integrated within human genes, including 2 into oncogenes. Finally, women with integrated HPV had a poorest outcome with a strong correlation between progression\u2010free survival and HPV integration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0035) and interestingly, the 2 HPV integrated into oncogenes were observed in patients who died from cancer. HPV genomic status seems to be a key prognostic factor in early stage cervical cancer, with HPV integration strongly linked to poor outcomes. Larger studies are needed to confirm the clinical relevance of HPV ID card for risk stratification and treatment decisions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.70720","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:33:34Z","timestamp":1764074014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HPV Genomic Status in Early Cervical Cancer and Its Prognosis Association"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4468-6660","authenticated-orcid":false,"given":"Imane","family":"Doghman","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"},{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Montero\u2010Mac\u00edas","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Hospital Center of Poissy Saint\u2010Germain\u2010en\u2010Laye Poissy France"},{"name":"Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5600-5797","authenticated-orcid":false,"given":"Victor","family":"Malassign\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"},{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Puech","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"},{"name":"Virology Laboratory, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Imbeaud","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Aude","family":"Le Fr\u00e8re\u2010Belda","sequence":"additional","affiliation":[{"name":"Pathology Department, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Rigolet","sequence":"additional","affiliation":[{"name":"Institut Curie, CNRS UMR 9187, Inserm U1196 Paris\u2010Saclay University Orsay France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Boulhic","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Gustave Roussy Cancer Campus Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Pathology Department, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina Aida","family":"Angeles","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Institut Universitaire du Cancer Toulouse Oncopole \u2013 Institut Claudius Regaud Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Mery","sequence":"additional","affiliation":[{"name":"Pathology Department Institut Universitaire du Cancer Toulouse Oncopole \u2013 Institut Claudius Regaud Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Sophie","family":"Bats","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Gynecologic and Breast Oncologic Surgery Department H\u00f4pital Europ\u00e9en Georges\u2010Pompidou, APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Centre de Recherche des Cordeliers Universit\u00e9 Paris Cit\u00e9, Inserm, Personalized Medicine Pharmacogenomics, Therapeutic Optimization Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Mathevet","sequence":"additional","affiliation":[{"name":"Department of Gynecology Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne Switzerland"},{"name":"Faculty of Biology and Medicine University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"L\u00e9curu","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Gynecologic oncology Department Institut Curie Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Veyer","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"},{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Virology Laboratory, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-4238","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"P\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Inserm Universit\u00e9 Paris Cit\u00e9, Functional Genomics of Solid Tumors Laboratory Paris France"},{"name":"Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Virology Laboratory, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou APHP Centre \u2013 Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Cancer Today https:\/\/gco.iarc.who.int\/today\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2021.32.e83"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90070-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2023.105418"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.01.026"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2018.12.008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjgenmed.2016.4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0432"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.02.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.02.002"},{"key":"e_1_2_11_14_1","first-page":"834","article-title":"viroCapt: A Bioinformatics Pipeline for Identifying Viral Insertion in Human Host Genome","volume":"294","author":"Wack M.","year":"2022","journal-title":"Studies in Health and Technology Informatics"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001216"},{"key":"e_1_2_11_16_1","unstructured":"L.Bruni G.Albero B.Serrano et al. ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre) Human Papillomavirus and Related Diseases in the World Summary Report 10 march 2023 (2023)."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01097-3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01153-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21386"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-012-0017-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37871-2"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27906"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.06.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0009"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01651-9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1115943\/full"},{"issue":"4","key":"e_1_2_11_27_1","first-page":"1441","article-title":"High Resolution Analysis of the Intracellular Proteome of Cervical Cancer Cell Lines Unveils Novel Regulators of Cervical Carcinogenesis","volume":"42","author":"Pappa K. I.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11120"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-84254-x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22689"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.810864\/full"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29872"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119566"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3178"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13559"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009875"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12933"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201500063"},{"issue":"5","key":"e_1_2_11_39_1","first-page":"663","article-title":"UDP\u2010Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K\/AKT Pathway","volume":"51","author":"Zhang F.","year":"2021","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_11_40_1","unstructured":"Clinical Significance of miR\u201025\u20103p and ZEB2 expression in Cervical Cancer and Their Effects on Proliferation and Invasion of Cervical Cancer Cells https:\/\/doi.org\/10.3969\/j.issn.2095-5227.2022.11.013."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504018X15201124340860"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33359-w"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.09.004"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2022.100211"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.941676"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:10:43Z","timestamp":1771312243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jmv.70720"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70720","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70720"}}