{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:43:16Z","timestamp":1790934196989,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human norovirus has been identified as a significant causative agent of acute gastroenteritis on a global scale. We investigated the epidemiological of norovirus infections in children with acute gastroenteritis in Shanghai between January 2022 and December 2024. The overall prevalence of norovirus was 13.22% (281\/2126), with annual rates of 3.77% (20\/531) in 2022, 18.30% (149\/814) in 2023, and 14.34% (112\/781) in 2024. The 281 norovirus strains were classified into the GI group (0.71%, 2\/281) and GII group (99.29%, 279\/281). Phylogenetic analysis revealed that 90.39% (254\/281) of HuNoV strains were successfully genotyped for both VP1 and RdRp genes, with 15 distinct genotype combinations. The most prevalent strain was GII.4 Sydney[P16] (52.36%, 133\/254), followed by GII.17[P17] (21.26%, 54\/254) and GII.3[P12] (11.42%, 29\/254). Of note, GII.4 Sydney[P16] was observed in both 2022 (56.25%, 9\/16) and 2023 (74.10%, 103\/139), while GII.17[P17] emerged as the predominant genotype in 2024 (43.43%, 43\/99). Furthermore, most of the GII.17[P17] strains identified in 2024 clustered with GII.17[P17] strains identified in the United States in 2025. These findings provide new insights into the genetic diversity of HuNoV and indicate a resurgence of a new GII.17[P17], which has become a leading cause of sporadic AGE in children in Shanghai.<\/jats:p>","DOI":"10.1002\/jmv.70729","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:38:07Z","timestamp":1764675487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resurgence and Predominance of GII.17[P17] Norovirus in Children With Sporadic Acute Gastroenteritis in Shanghai, China"],"prefix":"10.1002","volume":"97","author":[{"given":"Li\u2010juan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-4551","authenticated-orcid":false,"given":"Hua\u2010qing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-1970","authenticated-orcid":false,"given":"Peng\u2010cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun\u2010hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Children\u2032s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30059-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1961465"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02037-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vez048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2024.199486"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01144-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00075-14"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virs.2023.08.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001318"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae440"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3001.231003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virs.2023.04.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.01.025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17060794"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4360-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27340"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-022-00050-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2025.102762"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16060925"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13010003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1593610"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00691-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02498-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003677"},{"key":"e_1_2_10_26_1","first-page":"1","article-title":"The Emergence of Recombinant Norovirus GII.12[P16] and Predominance of GII.3[P12] Strains In Pediatric Patients With Acute Gastroenteritis in Thailand, 2019\u20132020","volume":"95","author":"Phengma P.","year":"2022","journal-title":"Journal of Medical Virology"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2354"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.39.2400625"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.002118"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15061336"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.102499"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2025.105809"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-021-00430-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03056-12"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70729","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:10:56Z","timestamp":1771312256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jmv.70729"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70729","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70729"}}