{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:14:59Z","timestamp":1788394499328,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the impact of preconception maternal inactivated COVID\u201019 vaccination on fetal metabolic recovery following maternal SARS\u2010CoV\u20102 infection during pregnancy. Umbilical cord blood samples were collected from neonates born to mothers with SARS\u2010CoV\u20102 infection during pregnancy. Mothers were stratified into two groups: those fully vaccinated (inactivated COVID\u201019 vaccines) before conception (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200981) and unvaccinated (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200956). Ultra\u2010performance liquid chromatography\u2010tandem mass spectrometry (UPLC\u2010MS\/MS) was employed for metabolomic profiling. The vaccinated group exhibited markedly reduced amino acid\/purine metabolism dysregulation and oxidative stress compared to unvaccinated counterparts. Crucially, within the critical IRT window of 5\u20136 months, vaccination effectively suppressed\n                    <jats:italic>m<\/jats:italic>\n                    TOR signaling\u2010driven pathological metabolic remodeling. In contrast, the unvaccinated group demonstrated sustained metabolic disturbances (&gt;\u20096 months from infection). In conclusion, preconception maternal inactivated COVID\u201019 vaccination reprograms fetal metabolism and accelerates intrauterine recovery from maternal SARS\u2010CoV\u20102 infection, which may confer a beneficial impact on early\u2010life growth. It prevents the establishment of a detrimental \u201cmetabolic memory\u201c effect posing potential developmental risks. These findings reveal a novel non\u2010immune, metabolome\u2010mediated protective mechanism of maternal vaccination, which thus supports COVID\u201019 vaccination for women of childbearing age.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70740","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:51:45Z","timestamp":1764935505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preconception COVID\u201019 Vaccination Reprograms Fetal Metabolism to Accelerate Intrauterine Recovery and Suppress Persistent Metabolic Memory"],"prefix":"10.1002","volume":"97","author":[{"given":"Roujie","family":"Huang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 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