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However, the precise relationship between DN and HBV integration remains unclear. We performed HBV\u2010capture sequencing on 19 cirrhosis patients with HBV infection (DN, 10; RN, 9), out of which 10 subjects (DN, 9; RN, 1) underwent RNA sequencing. In total, 1936 and 1450 HBV integration sites were identified in the DN and RN samples, respectively. The number of HBV integration sites in DN correlated with nodule size. Breakpoints in HBV genome were concentrated within 100\u2009bps toward the 5\u2032 or 3\u2032 end of involved HBV genes. Furthermore, integration numbers also positively correlated with number of point mutations in DN samples. We identified 53 and 29 recurrent genes containing HBV integrations in \u2265\u20092 samples in DN and RN samples, respectively. Higher clonality was observed for HBV integrations in recurrent genes than other HBV\u2010integrated genes. The HBV integrations in recurrent genes were predominantly located in intron regions. Notably, among those recurrently HBV\u2010integrated genes in DN samples,\n                    <jats:italic>SCHIP1<\/jats:italic>\n                    ,\n                    <jats:italic>ZDHHC14<\/jats:italic>\n                    ,\n                    <jats:italic>YPEL2<\/jats:italic>\n                    ,\n                    <jats:italic>RABGAP1L<\/jats:italic>\n                    , and\n                    <jats:italic>SOX5<\/jats:italic>\n                    displayed significant expression alterations. Moreover, clinical indicators revealed significant prolongation of prothrombin time in two DN patients with HBV integrations in\n                    <jats:italic>SCHIP1<\/jats:italic>\n                    and\n                    <jats:italic>ZDHHC14<\/jats:italic>\n                    . As a new insight regarding HBV integrations in DN stage, our findings suggest a possible role of HBV integration in the transformation of DN to early\u2010stage liver cancer by affecting the expression of key genes.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70755","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:02:02Z","timestamp":1767812522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Hepatitis B Virus Integration Reveals New Insights of Oncogenic Mechanism in Dysplastic Liver Nodule"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-0773","authenticated-orcid":false,"given":"Xi","family":"Zeng","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatic, 3D Genomics Research Center, College of Informatics Huazhong Agricultural University Wuhan 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