{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:42:11Z","timestamp":1769539331340,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    HIV controllers (HICs) maintain low\u2010level viremia and normal CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts without antiviral therapy (ART). This study aimed to characterized immunophenotypic and reservoir dynamics in Chinese HICs, revealing key distinctions from normal progressors (NPs). This prospective single\u2010center study enrolled HICs (ART\u2010free HIV RNA\u2009&lt;\u20092000\u2009copies\/mL \u2265\u200912 months) and age\/sex\u2010matched NPs served as controls at PUMCH (2000\u20132024). Longitudinal immunophenotyping of PBMCs was performed and used PCR to detected total HIV\u20101 DNA. Among 1792 PLWH, 46 (2.5%) HICs (median age 31 years, 69% male) were enrolled in this study underwent 6 (5\u201312.5) years follow\u2010up, including 8 elite controllers and 38 viral controllers. Baseline CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts were 567 (507\u2013757) cells\/\u03bcL, VL 2.64 (2.35\u20132.98) log10 copies\/mL. Compared with NPs, HICs exhibited higher NK\u2010cell percentage, B\u2010cell percentage, naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts and CD4\/CD8 ratio, lower activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells (CD38\n                    <jats:sup>+<\/jats:sup>\n                    orHLA\u2010DR\n                    <jats:sup>+<\/jats:sup>\n                    ) percentage and total HIV\u2010DNA at baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). ART reduced HIV\u2010DNA in NPs but remained higher than HICs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Five HICs discontinued follow\u2010up, 43.9% (18\/41) HICs lost virological control at 6 (5\u20139) years. HICs experiencing lost virological control exhibited elevated baseline HIV\u2010DNA, activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells percentage and lower CD4\/CD8 ratio. Preceding control loss, declining CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts (predominantly naive subsets), CD4\/CD8 ratios and rising activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells percentage were observed. Conversely, HICs maintaining virological control retained stable CD38\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell percentages, CD4\/CD8 ratio and naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts exhibited increased elevated HLA\u2010DR\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell percentage. Chinese HICs exhibit different immunophenotypes with reduced HIV\u2010DNA versus NPs. Longitudinal tracking of HIV\u20101 DNA, activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell, na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell dynamics, and CD4\/CD8 stability predict virologic failure in HICs.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70756","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:29:02Z","timestamp":1768382942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chinese HIV Controllers Exhibit Different Immunophenotypic Profiles and Viral Reservoir Dynamics Compared to Normal Progressors: A Real\u2010World Cohort Study"],"prefix":"10.1002","volume":"98","author":[{"given":"Fada","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-5675","authenticated-orcid":false,"given":"Taisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Peking Union Medical College Hospital Beijing China"},{"name":"Tsinghua\u2010Peking Center for Life Sciences Beijing China"},{"name":"Department of Basic Medical Sciences, School of Medicine Tsinghua University Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.030"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00328-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.08.010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000049"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58696-y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02338-17"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103118"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.12.009"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803928"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.01.034"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00015-16"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001050"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25675"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100894"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832b44c8"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001825"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/646609"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01790-18"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29646"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.05.029"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw163"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000822"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.124.017033"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835a9950"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz442"},{"key":"e_1_2_13_27_1","first-page":"585","article-title":"The Risk of Non\u2010AIDS Defining Events Is Lower in ART\u2010Naive HIV Controllers Than in Normal Progressors on Suppressive ART","author":"Groenendijk A. 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