{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:09:49Z","timestamp":1781258989856,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072271"],"award-info":[{"award-number":["82072271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241072"],"award-info":[{"award-number":["82241072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472266"],"award-info":[{"award-number":["82472266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Stem cell\u2010like memory T cells (T\n                    <jats:sub>SCM<\/jats:sub>\n                    ) play a pivotal role at the top of the memory T cell hierarchy, understanding their involvement in immune exhaustion during HIV infection may shed light on T cell dysfunction mechanisms. We compared cellular immunity between virally suppressed people living with HIV (PLWH) under antiretroviral therapy (ART) and HIV\u2010negative subjects. Flow cytometry was used to assess the phenotype and function of peripheral T\n                    <jats:sub>SCM<\/jats:sub>\n                    . T\n                    <jats:sub>SCM<\/jats:sub>\n                    showed a reduction in the expression level of TCF\u20101, T\u2010bet, as well as in multifunctional capacity, which was reflected by decreased secretion of IL\u20102\n                    <jats:sup>+<\/jats:sup>\n                    TNF\u2010a\n                    <jats:sup>+<\/jats:sup>\n                    INF\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    cells in PLWH. The decreased frequencies of IL\u20102\n                    <jats:sup>+<\/jats:sup>\n                    TNF\u2010a\n                    <jats:sup>+<\/jats:sup>\n                    INF\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>SCM<\/jats:sub>\n                    was positively correlated with the reduced frequency of T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    in T cells. An increased mean fluorescence intensity of TOX was observed in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>SCM<\/jats:sub>\n                    from PLWH. The frequency of T progenitor exhausted\u2010like cells (T\n                    <jats:sub>PEX<\/jats:sub>\n                    ) within CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells was positively associated with the frequency of GZMK\n                    <jats:sup>+<\/jats:sup>\n                    cells in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>SCM<\/jats:sub>\n                    . In addition, the frequency of stem\u2010like T cells (T\n                    <jats:sub>STEM<\/jats:sub>\n                    ) in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells was positively correlated with the frequency of T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    cells in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>SCM<\/jats:sub>\n                    . T\n                    <jats:sub>SCM<\/jats:sub>\n                    from virally suppressed PLWH exihibt impaired stemness and multipotency, potentially contributing to poor immune reconstitution.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70761","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:49:46Z","timestamp":1766404186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Residual Exhaustion of Stem Cell\u2010Like Memory T Cells (T\n                    <sub>SCM<\/sub>\n                    ) in HIV Infected Patients With Viral Suppression"],"prefix":"10.1002","volume":"97","author":[{"given":"Jing","family":"Xiao","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Department of Liver Disease Center, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5140-0440","authenticated-orcid":false,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-4785","authenticated-orcid":false,"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino\u2010French Joint Laboratory for HIV\/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31910"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000000572"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.646447"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47050367"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000002792"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14112395"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.08.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104253"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1152951"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1530"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01471-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-090222-110914"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0791-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2446"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2017.0017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01219-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016279"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-322727"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136648"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.02.161"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.149"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(10)70026-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416643852"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204416"},{"key":"e_1_2_9_27_1","unstructured":"Y.Shen \u201cChinese Guidelines for Diagnosis and Treatment of Human Immunodeficiency Virus Infection\/Acquired Immunodeficiency Syndrome (2024 edition) \u201dChinese Journal of Virology(2025) https:\/\/link.cnki.net\/doi\/10.16505\/j.2095-0136.2025.0001."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000003167"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105667"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2271068"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz442"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01948-14"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00492-16"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00169"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci157549"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.725618"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00750-4"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9563-2"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186497"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12823"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70761","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:11:08Z","timestamp":1771312268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jmv.70761"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70761","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70761"}}