{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:51:21Z","timestamp":1791701481127,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant lesion with the potential to progress to invasive vaginal carcinoma, yet its clinical characteristics and associated risk factors remain incompletely defined. This retrospective study evaluated the prevalence, human papillomavirus (HPV) genotype distribution, and clinical risk factors of VaIN in women undergoing colposcopy. A total of 8206 patients who received colposcopic examination and vaginal biopsy due to abnormal ThinPrep cytologic test results and\/or high\u2010risk HPV positivity between January 2021 and December 2023 were reviewed. Patients with cervical cancer, vulvar intraepithelial lesions, or condyloma acuminatum were excluded. Clinical characteristics, HPV genotypes, cytology findings, and histopathological results were analyzed. VaIN was diagnosed in 682 patients (8.22%). The most prevalent HPV genotypes were HPV16, HPV52, HPV58, and HPV53. High\u2010grade VaIN (VaIN3) occurred more frequently in older and postmenopausal women. Concurrent VaIN and cervical intraepithelial neoplasia was significantly associated with advanced age, postmenopausal status, multiple HPV infections, and a history of cervical intraepithelial neoplasia. Among women with prior hysterectomy, VaIN was more commonly observed after hysterectomy for cervical lesions, although 24.7% of cases followed hysterectomy for non\u2010cervical indications. In non\u2010hysterectomized patients, 98.2% of VaIN lesions were located in the upper third of the vagina. Multivariate analysis identified older age, postmenopausal status, and multiple HPV infections as independent risk factors for VaIN. These findings underscore the importance of vigilant vaginal surveillance, particularly in women with persistent or multiple HPV infections and those with a history of hysterectomy.<\/jats:p>","DOI":"10.1002\/jmv.70766","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:39:58Z","timestamp":1766489998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human Papillomavirus\u2010Associated Risk Factors and Clinical Characteristics of Vaginal Intraepithelial Neoplasia: A Retrospective Study"],"prefix":"10.1002","volume":"98","author":[{"given":"Xiaofeng","family":"Shi","sequence":"first","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Lian","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfen","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Shang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-622"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.03.033"},{"key":"e_1_2_12_5_1","unstructured":"X. U.Ying L. I.Zhu\u2010nan C. H. E. N.Yi S. H. I.Wei W. A. N. G.Li\u2010ya andW. U.Dan \u201cClinical Analysis of 56 Cases With Vaginal Intraepithelial Neoplasia After Hysterectomy \u201dJournal of Shanghai Jiaotong University (Medical Science)37 no.5:661\u2013665 https:\/\/doi.org\/10.3969\/j.issn.1674-8115.2017.05.018."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006700"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000563"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.0807"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21628"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-004213"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.023"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14733"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5894801"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28595"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.023"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29267"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27953"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-07940-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27354"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2021-002577"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02739-x"},{"issue":"12","key":"e_1_2_12_22_1","first-page":"2823","article-title":"Colposcopic Patterns of Vaginal Intraepithelial Neoplasia: A Focus on Low\u2010Grade Lesions","volume":"21","author":"Sopracordevole F.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:39:08Z","timestamp":1769492348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jmv.70766"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70766","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"2025-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70766"}}