{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:25:49Z","timestamp":1769541949996,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004612","name":"Arauc\u00e1ria Foundation","doi-asserted-by":"publisher","award":["DT2022271000064"],"award-info":[{"award-number":["DT2022271000064"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by\n                    <jats:italic>Human betaherpesviruses<\/jats:italic>\n                    (HCMV, HHV\u20106, and HHV\u20107). Studies have suggested that these viruses play potential oncogenic role in hematological neoplasms, although results remain inconclusive. This study aimed to evaluate the frequency and viral load of betaherpesviruses in saliva samples from patients with hematological neoplasms, and to explore their relevance to clinicopathological characteristics. In total, 260 saliva samples collected from patients with Hodgkin lymphoma (HL) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929), non\u2010Hodgkin lymphoma (NHL) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009106), leukemia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200985) and multiple myeloma (MM) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) were analyzed in multiplex qPCR. The result was compared with control group samples from patients without hematological neoplasm (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009159). HHV\u20107 was the most frequently detected betaherpesvirus, identified in 15.8% (41\/260) of patients with hematological neoplasms. In comparison, HCMV and HHV\u20106 were detected in 12 (4.6%) and 11 (4.2%) patients, respectively. In the control group, HCMV was detected in 2 individuals (1.3%), HHV\u20106 in 6 (3.8%), and HHV\u20107 in 14 (8.8%). A statistically significant difference in HHV\u20107 detection was observed between patients and controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Additionally, HCMV detection showed a significant difference between patients with HL and MM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). The detection of betaherpesviruses, particularly HHV\u20107, was more frequent and viral in patients with hematologic malignancies compared to the control group, with statistically significant differences observed. In summary, HHV\u20107 was the most frequently detected virus, found in 15.8% of patients versus 8.8% of controls. However, its presence in saliva alone does not confirm disease association. Our findings reinforce the need for longitudinal studies to clarify the potential pathogenic role of HHV\u20107 and other betaherpesviruses in hematological neoplasms, and their possible impact on patient outcomes.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70770","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:37:11Z","timestamp":1767775031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights"],"prefix":"10.1002","volume":"98","author":[{"given":"Ana Carolina Silva","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Foundation Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Pereira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Microbiology Department Biological Sciences Center State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nath\u00e1lia de Sousa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Microbiology Department Biological Sciences Center State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Freitas de Oliveira","family":"Bonfim","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Foundation Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrini Guidolini","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Social Medicine Department Federal University of Esp\u00edrito Santo Vitoria Esp\u00edrito Santo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marla Karine","family":"Amarante","sequence":"additional","affiliation":[{"name":"Pathology, Clinical and Toxicological Analysis Department Health Sciences Center State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sueli Fumie","family":"Yamada\u2010Ogatta","sequence":"additional","affiliation":[{"name":"Microbiology Department Biological Sciences Center State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Cinquini","family":"Franco","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department Health Sciences Center, Londrina Cancer Hospital State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia Carla Faccin","family":"Galhardi","sequence":"additional","affiliation":[{"name":"Microbiology Department Biological Sciences Center State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-754X","authenticated-orcid":false,"given":"Vanessa Salete","family":"de Paula","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Foundation Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75387-2_149"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS13123023\/S1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/BCJ.2015.29"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00853-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1189805"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12080993"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS25147502"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMV.24690"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1981-1983.2000"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRANSPROCEED.2025.02.023"},{"key":"e_1_2_11_12_1","volume-title":"Cytomegalovirus","author":"Gupta M.","year":"2025"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1202138"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27016"},{"key":"e_1_2_11_15_1","unstructured":"U. 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