{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:28:09Z","timestamp":1769542089598,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To evaluate the durability of long\u2010acting cabotegravir (CAB) plus rilpivirine (RPV), available in Italy since June 2022, for maintaining HIV\u20101 virological suppression. This multicentric observational study included 191 virologically suppressed adults (HIV\u2010RNA\u2009&lt;\u200950 copies\/mL) from 11 centers in Tuscany, followed from first CAB\u2009+\u2009RPV injection until discontinuation, death, or last visit. Discontinuation was defined as regimen switch or two consecutive missed doses, virological failure (VF) as two consecutive HIV\u2010RNA\u2009&gt;\u200950 copies\/mL or a single &gt;\u20091000 copies\/mL. Kaplan\u2013Meier survival analysis assessed discontinuation rates. Follow\u2010up was 209.5 person\u2010years with a median of 1 year (IQR 0.5\u20131.5). Median age was 51 years (IQR 43\u201358); 81.7% were male; median ART duration was 13.8 years (IQR 8.7\u201320.2). Eighteen participants (9.2%) discontinued due to adverse events (3.7%), VF (2.6%), personal choice (2.1%), medical decision (0.5%), or loss to follow\u2010up (0.5%). Overall discontinuation was 8.5\/100 person\u2010years (95% CI: 5.4\u201313.6). VF incidence was 2.3\/100 person\u2010years (95% CI 0.9\u20135.7). All VFs, occurred within 28 weeks, except one at Week 72 with resistance mutations. Discontinuation rates were slightly higher than clinical trials but consistent with real\u2010world data. The VF incidence was slightly higher than reported in prior reports, highlighting the need for real\u2010life clinical monitoring.<\/jats:p>","DOI":"10.1002\/jmv.70779","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:33:59Z","timestamp":1767008039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Durability of Long\u2010Acting Cabotegravir\u2009+\u2009Rilpivirine in Virologically Suppressed Adults Living With HIV: A Multicenter Observational Cohort in Tuscany (LAHIV)"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0999-6070","authenticated-orcid":false,"given":"Filippo","family":"Lagi","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit Azienda Ospedaliero\u2010Universitaria Careggi Florence 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