{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:22:50Z","timestamp":1769538170503,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Orthobunyavirus oropoucheense<\/jats:italic>\n                    (OROV) causes Oropouche fever, which exhibits symptoms similar to those of other arboviral diseases. Although it has historically been restricted to the Amazon region, the virus has recently spread to other areas of Brazil. Alagoas state, with low socioeconomic conditions and limited health coverage, has seen an increase in febrile cases without confirmed molecular diagnoses of circulating arboviruses. By September 6, 2024, 1316 samples negative for Dengue, Zika, and Chikungunya were tested for OROV and Mayaro virus using RT\u2010qPCR, yielding 115 (8.74%) positive results for OROV. Among these, 14 (22.22%) viral isolates were obtained in Vero cells and confirmed by RT\u2010qPCR and immunofluorescence assay (IFA). The study generated 37 new near\u2010complete genomic sequences corresponding to the newly characterized OROV lineage and examined selection pressures on the M gene, identifying sites under purifying selection. We identified amino acid variations in the Gc glycoprotein structure at positions 507, 552, 738, and 795, which may influence host\u2010cell interactions. This work is the first to report OROV in Alagoas, emphasizing the need for improved monitoring and control measures to mitigate public health impacts.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70780","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:43:13Z","timestamp":1767008593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arrival of Oropouche Virus in a Nonendemic Area in Northeastern Brazil, 2024"],"prefix":"10.1002","volume":"98","author":[{"given":"Jean P. M.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas Macei\u00f3 Alagoas Brazil"},{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago P. G.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykaella A.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco Paulo Afonso Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateus M. G.","family":"Arruda","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit\u00f3ria P.","family":"Simplicio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelly B.","family":"Calheiros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline C.","family":"Pereira e Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M. N.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina Veterin\u00e1ria e Zootecnia Butant\u00e3 S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus R.","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magliones C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazerral O.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00canio J.","family":"Bassi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra A.","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson B.","family":"Leite","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9379-1686","authenticated-orcid":false,"given":"Abelardo","family":"Silva\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0672"},{"key":"e_1_2_9_3_1","first-page":"15","article-title":"Epidemia De V\u00edrus Oropouche Em Bel\u00e9m. 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