{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:21:45Z","timestamp":1769538105543,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>There is evidence that persistent dysregulation of the immune system caused by SARS\u2010CoV\u20102 infection may increase susceptibility to other infections. Here, we assessed whether it is associated with subsequent diagnoses of infectious mononucleosis due to Epstein\u2010Barr virus (EBV\u2010IM). Residents of Sweden aged 3\u2013100 years without a prior diagnosis of EBV\u2010IM were followed between January 1, 2020, and November 30, 2022, comprising a total of 9\u2009978\u2009860 participants. Individuals were categorized into those without a COVID\u201019 diagnosis, those with a positive SARS\u2010CoV\u20102 polymerase chain reaction (PCR) test only \u2013 less severe exposure, and those admitted to hospital with COVID\u201019 \u2013 more severe exposure. Cox regression was used to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for the association between the exposure, modeled as a time\u2010varying covariate, and EBV\u2010IM occurrence. EBV\u2010IM rates per 100\u2009000 person\u2010years and 95% CIs were 4.6 (4.4\u20134.9) for individuals not diagnosed with COVID\u201019, 7.8 (6.9\u20138.9) for those with a positive SARS\u2010CoV\u20102 test only, and 10.5 (6.2\u201317.6) for patients admitted to hospital with COVID\u201019. HR and 95% CI were 1.61 (1.39\u20131.88) for people with a positive PCR test only and 5.71 (3.33\u20139.79) for those admitted to hospital with COVID\u201019 compared with people without a COVID\u201019 diagnosis, after adjustment for birth year, sex, Swedish healthcare region, region of birth, and Charlson comorbidity index. SARS\u2010CoV\u20102 infection was associated with a subsequent raised risk of EBV\u2010IM, including among those with less severe acute infection, signaling immune perturbation and the possibility of further delayed sequelae linked with EBV\u2010IM.<\/jats:p>","DOI":"10.1002\/jmv.70787","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:24:03Z","timestamp":1767007443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SARS\u2010CoV\u20102 Infection Is Associated With an Increased Risk of Hospital\u2010Treated Infectious Mononucleosis due to EBV: National Register\u2010Based Cohort Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-3470","authenticated-orcid":false,"given":"Snieguole","family":"Vingeliene","sequence":"first","affiliation":[{"name":"Clinical Epidemiology and Biostatistics School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzan","family":"Udumyan","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Jendeberg","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunl\u00f6g","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sundqvist","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen A. 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