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Tat, an HIV\u20101 regulatory protein, also modulates transcription in host cells. However, the mechanisms by which Tat stably affects macrophage functions, critical host cells for HIV\u20101, remain unclear. This study demonstrates that Tat promotes macrophage proliferation, migration, and phagocytosis. In\u2010depth analysis reveals that HIV\u20101 Tat enhances lactate accumulation, induces reactive oxygen species (ROS), and activates the MAPK pathway in macrophages. Additionally, lactate induces autophagy activation, leading to increased levels of Arg1 and TGF\u2010\u03b2, which drive phagocytosis and migration, respectively. By examining the activity of macrophages stably infected with Tat, this study provides new insights into Tat\u2032s latent influence on macrophage function, offering theoretical support for understanding HIV\u20101 infection mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70788","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:04:09Z","timestamp":1767773049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endogenous HIV\u20101 Tat Promotes Cell Proliferation, Migration, and Phagocytosis in Stably Infected Macrophages by Accumulating Lactate and Activating the Autophagy\/MAPK Pathway"],"prefix":"10.1002","volume":"98","author":[{"given":"Yang","family":"Wei\u2010ling","sequence":"first","affiliation":[{"name":"Graduate School, Youjiang Medical University for Nationalities Baise Guangxi China"},{"name":"Basic Medical School, Youjiang Medical University for 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