{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:06:20Z","timestamp":1769540780742,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["115\u2010S0157"],"award-info":[{"award-number":["115\u2010S0157"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Serum Mac\u20102 binding protein glycosylation isomer (M2BPGi) formation requires sugar chain glycosylation on M2BP. Whether glycated hemoglobin (HbA1c) levels affect M2BPGi in diagnosing hepatitis C virus (HCV)\u2010related hepatic fibrosis remains unclear. We enrolled 2064 patients with available M2BPGi, HbA1c, and valid vibration\u2010controlled transient elastography (VCTE) for fibrosis staging. Associations between M2BPGi and HbA1c levels across fibrosis stages were analyzed using Kruskal\u2013Wallis test and Spearman's correlation. Multivariable linear regression with Akaike information criterion (AIC) identified factors associated with M2BPGi levels. The diagnostic accuracy of M2BPGi in fibrosis staging was evaluated using the areas under receiver operating characteristics (AUROCs) with 95% confidence intervals (CIs). M2BPGi levels showed no correlation with HbA1c categories (&lt;\u20095.7%, 5.7%\u20136.4%, 6.5%\u20136.9%, 7.0%\u20137.9%, \u2265\u20098.0%) in fibrosis stages F2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.48), F3 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.63), or F4 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.22), except in F0\u2013F1 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Spearman's\n                    <jats:italic>\u03c1<\/jats:italic>\n                    for F0\u2013F1, F2, F3, and F4 were 0.086 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0088), 0.087 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.057), 0.056 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.41), and \u22120.023 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.62), respectively. Multivariable regression identified fibrosis stage (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    for F4, F3, F2 vs. F0\u2013F1\u2009=\u20094.2724, 1.7623, 0.7223;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), age (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.0159;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), ALT quotient (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.0094;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), steatosis (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.2460;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), but not HbA1c, as independent predictors of M2BPGi. The diagnostic accuracy of M2BPGi for fibrosis staging was comparable across HbA1c categories. In conclusion, HbA1c levels do not influence the diagnostic performance of M2BPGi for HCV hepatic fibrosis staging.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70797","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:40:31Z","timestamp":1768466431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Glycated Hemoglobin Levels on Serum Mac\u20102 Binding Protein Glycosylation Isomer in the Diagnosis of Hepatitis C\u2010Virus Related Hepatic Fibrosis"],"prefix":"10.1002","volume":"98","author":[{"given":"Yu\u2010Ping","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Biomedical Park Hospital Hsin\u2010Chu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Chu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yuh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch Douliou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yu","family":"Kao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Metabolism and Obesity Sciences Taipei Medical University Taipei Taiwan"},{"name":"TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan"},{"name":"Taipei Cancer Center Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Taipei City Hospital, Ren\u2010Ai Branch Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Shun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Kuan Tien General Hospital Taichung Taiwan"},{"name":"Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Lueng","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Yuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Digestive Medicine, Department of Internal Medicine China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Fu Jen Catholic University Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Chin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Bei\u2010Hu Branch Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Hung","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Biomedical Park Hospital Hsin\u2010Chu Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Medical Research National Taiwan University Biomedical Park Hospital Hsin\u2010Chu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai\u2010Chung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Medical Research National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei 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