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Genomic and epigenetic studies have revealed shared host genetic alterations\u2014most notably in JAK\u2013STAT signaling, epigenetic regulators, TP53, and DDX3X\u2014supporting a pathogenic and clinicobiological continuum across these disorders. Defective EBV further reshapes viral gene expression programs and contributes to oncogenesis.\n                    <jats:sc>l<\/jats:sc>\n                    \u2010asparaginase\u2010based chemoradiotherapy has improved outcomes in early\u2010stage ENKTL; however, effective treatments for advanced\u2010stage disease and other EBV\u2010associated T\/NK\u2010cell neoplasms remain limited. Emerging molecular subclassifications and large\u2010scale prospective cohorts can help clarify disease heterogeneity and accelerate the development of precision therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70798","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:06:09Z","timestamp":1767963969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epstein\u2013Barr Virus\u2010Associated T\/NK\u2010Cell Neoplasms"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-6413","authenticated-orcid":false,"given":"Yoshitaka","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Virology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Virology 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