{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:05:27Z","timestamp":1785524727243,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170640"],"award-info":[{"award-number":["82170640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30954"],"award-info":[{"award-number":["2022JJ30954"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Excessive inflammation and immune activation are strongly associated with unfavorable outcomes and elevated mortality rates in hepatitis B virus (HBV)\u2010related acute\u2010on\u2010chronic liver failure (ACLF). However, the role of the C\u2010reactive protein to lymphocyte ratio (CLR) as a prognostic inflammatory biomarker in multiple diseases is rarely mentioned in HBV\u2010ACLF. This investigation aimed to assess the utility of the CLR and additional parameters in identifying high\u2010risk progression in HBV\u2010ACLF patients. A cohort of 639 hospitalized patients diagnosed with HBV\u2010ACLF based on the APASL criteria was divided into two cohorts: 447 cases in the training set and 192 cases in the validation set. Logistic regression analysis was employed to identify the XY\u2010model. The results of multiple factor analysis showed that the incidence of liver cirrhosis, age, CLR, serum total bilirubin, calcium, prothrombin activity, and alpha fetoprotein affect the prognosis of HBV\u2010ACLF. CLR emerged as a significant independent risk factor for disease progression in patients with ACLF (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.01\u20131.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The novel model based on seven predictors could accurately predict short\u2010term mortality in patients with HBV\u2010ACLF, which is promising for guiding clinical management and addressing the etiological differences in Asian populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.70799","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T11:45:23Z","timestamp":1769255123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Systemic Inflammation\u2010Based Model for Predicting Mortality in HBV\u2010Related ACLF"],"prefix":"10.1002","volume":"98","author":[{"given":"Wenting","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-1254","authenticated-orcid":false,"given":"Lei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31865-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1011-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.12.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28740"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00476"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021428"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i28.1133"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.045"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9580-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29276"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63900-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2500490"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S510755"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001273"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17776"},{"key":"e_1_2_9_24_1","first-page":"313","article-title":"C\u2010Reactive Protein and the Acute Phase Response","volume":"37","author":"Ballou S. P.","year":"1992","journal-title":"Advances in Internal Medicine"},{"key":"e_1_2_9_25_1","first-page":"368","article-title":"Serum High\u2010Sensitivity C\u2010Reactive Protein Are Associated With HBV Replication, Liver Damage, and Fibrosis in Patients With Chronic Hepatitis B","volume":"62","author":"Ma L. N.","year":"2015","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.01.009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29702"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0378-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46047-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.07.008"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:41:06Z","timestamp":1785519666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jmv.70799"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70799","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70799"}}