{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:51:22Z","timestamp":1772985082207,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated whether plasma cytomegalovirus (CMV) IL\u201010 (cmvIL\u201010) levels could serve as a biomarker of active CMV replication in allogeneic hematopoietic transplant recipients (allo\u2010HCT) in the presence or absence of letermovir (LMV) prophylaxis. A total of 189 leftover plasma samples that tested positive for CMV DNA (Alinity\n                    <jats:italic>m<\/jats:italic>\n                    CMV assay), representing 33 episodes of CMV DNAemia were run on a laboratory\u2010developed enzyme\u2010linked immunosorbent assay for cmvIL\u201010 quantification. Eighteen episodes developed during LMV prophylaxis. Overall, 16 episodes of CMV DNAemia were classified as clinically significant (CsCMVi). There was an overall very weak correlation between the two biomarkers (Rho = 0.10;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.16). Overall, the median cmvIL\u201010 area under the curve (AUC) until CMV DNA levels reached their peak was significantly higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in CsCMVi episodes than in non\u2010CsCMVi episodes. cmvIL\u201010 AUC between Days 14 and 23 after allo\u2010HCT (AUC\u2081\u2084\u208b\u2082\u2083) values were significantly higher in CsCMVi episodes compared with non\u2010CsCMVi episodes among patients receiving LMV therapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). An AUC\u2081\u2084\u208b\u2082\u2083 cutoff value of log\n                    <jats:sub>10<\/jats:sub>\n                    3.06 discriminated anticipately between CsCMVi and non\u2010CsCMVi with a sensitivity and specificity of 100%. Plasma cmvIL\u201010 levels may reflect true CMV replication and thus provide a unique perspective on viral dynamics, serving as an ancillary marker to CMV DNA monitoring.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70806","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:04:25Z","timestamp":1768302265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomegalovirus IL\u201010 in Plasma as a Marker of Active Infection in Allogeneic Hematopoietic Transplant Recipients: An Exploratory Study"],"prefix":"10.1002","volume":"98","author":[{"given":"\u00c1ngela","family":"S\u00e1nchez\u2010Simarro","sequence":"first","affiliation":[{"name":"Microbiology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseo","family":"Albert","sequence":"additional","affiliation":[{"name":"Microbiology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-9790","authenticated-orcid":false,"given":"Estela","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Microbiology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Colomer","sequence":"additional","affiliation":[{"name":"Microbiology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hematology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2562","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"Hematology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[{"name":"Hematology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"},{"name":"Department of Medicine School of Medicine University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-4110","authenticated-orcid":false,"given":"David","family":"Navarro","sequence":"additional","affiliation":[{"name":"Microbiology Service Clinic University Hospital, INCLIVA Health Research Institute Valencia Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Microbiology School of Medicine University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"issue":"25","key":"e_1_2_10_2_1","article-title":"Recommendations From the 10th European Conference on Infections in Leukaemia for the Management of Cytomegalovirus in Patients After Allogeneic Haematopoietic Cell Transplantation and Other T\u2010Cell\u2010Engaging Therapies","volume":"1473","author":"Ljungman P.","year":"2025","journal-title":"Lancet 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