{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:17:57Z","timestamp":1785536277816,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Enteroviruses (EVs) cause a spectrum of illnesses ranging from mild to severe, including neurological complications. In this study, the molecular epidemiology, clinical impact, and seasonality of EVs were evaluated among hospitalized patients in a large tertiary medical center in Israel from 2016 to 2024. A total of 11,246 cerebrospinal fluid (CSF) samples and 5,744 stool samples were tested for EV RNA using RT\u2010PCR, with 7.1% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009798) and 19.3% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091,110) testing positive, respectively. Positive samples were sequenced for genotype identification based on partial VP1 sequences with 70% genotype identification. The most commonly detected subtypes in CSF samples were: E\u201018 (16.4%), E\u20105 (80\/567, 14.1%), E\u20106 (67\/567, 11.8%), E\u201030 (64\/567, 11.3%), CVB5 (37\/567, 6.5%), E\u20104 (29\/567, 5.1%), and CVB2 (28\/567, 4.9%). These subtypes were also detected in stool samples during similar time periods. Seasonal analyses showed the expected summer peaks with unexpected off\u2010season outbreaks in 2016, 2017, and 2022\u20132024. Additionally, EV positivity rates declined significantly during the SARS\u2010CoV\u20102 pandemic (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) followed by a resurgence in 2022\u20132023. Phylogenic analysis revealed genomic shifts in CVB2, E\u20105, E\u20106, E\u201018, and E\u201030, whereas CVB5 and E\u20104 showed no significant variations. CVB2 infections were particularly associated with severe illness in infants, with 10.6% of all sequenced cases requiring ICU admission. These findings demonstrate dynamic changes in EV epidemiology in Israel, including shifts in seasonality, genotype variability, and the impact of SARS\u2010CoV\u20102 on EV circulation, highlighting the importance of continued molecular surveillance for identifying emerging strains and better understand trends relevant to public health.\u00a0\n                  <\/jats:p>","DOI":"10.1002\/jmv.70810","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:46:51Z","timestamp":1768556811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology of Enteroviruses Among Hospitalized Patients in Israel (2016\u20132024): CNS Involvement, Subtype Variability, and Seasonality"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-8022","authenticated-orcid":false,"given":"Ilana S.","family":"Fratty","sequence":"first","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"The Israel Center for Disease Control Israel Ministry of Health  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or","family":"Kriger","sequence":"additional","affiliation":[{"name":"Public Health Services Ministry of Health  Israel"},{"name":"School of Public Health Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Weiss","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat","family":"Vasserman","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reut","family":"Gabai","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oran","family":"Erster","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharona","family":"Glatman\u2010Freedman","sequence":"additional","affiliation":[{"name":"The Israel Center for Disease Control Israel Ministry of Health  Ramat\u2010Gan Israel"},{"name":"School of Public Health Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Lustig","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"School of Public Health Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danit","family":"Sofer","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merav","family":"Weil","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Ministry of Health and Sheba Medical Center  Ramat\u2010Gan 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