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The pathophysiology of these complications is not fully understood, but they have been linked to host immune responses, particularly a proinflammatory Th1\/Th17 profile. In this study, the kinetics of 14 cytokines were characterized in ZIKV\u2010infected patients recruited in French Guiana in 2016\u20132017. Cytokine concentrations were quantified using a multiplexed bead\u2010based immunoassay in serum samples collected sequentially from 36 patients during the first month after symptom onset. This longitudinal follow\u2010up provides chronological information on the immune response to mild\u2010to\u2010moderate ZIKV infection, with an early antiviral response dominated by IFN\u2010\u03b3, TNF\u2010\u03b1 and regulated by IL\u201010, followed by a peak of Th1 and then Th17\u2010associated cytokines that persists for up to 1 month. The early presence of IL\u201017A, IL\u201021, and IL\u201023 was positively correlated with the maximum amplitude of the serological response (total anti\u2010ZIKV IgG and seroneutralization titers), but also with the duration of neurological symptoms (paresthesia and muscle strength decrease), highlighting the bivalent role of Th17 immune response in ZIKV pathogenesis.<\/jats:p>","DOI":"10.1002\/jmv.70813","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:31:36Z","timestamp":1768912296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Monitoring of Systemic Cytokines After Mild Zika Virus Infection Revealed an Association Between Th17 Polarization and Clinical and Serological 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