{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:55:22Z","timestamp":1789631722889,"version":"build-2803163510"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epstein\u2010Barr virus (EBV) infection has been studied at single\u2010cell resolution for six decades and counting. Such investigations can reveal virus\u2010host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time. Understanding these factors is paramount to treating EBV\u2010associated cancers and autoimmune diseases. This review examines the state of the field in EBV single\u2010cell and spatial\u2010omics spanning experimental models and clinical samples. Topics of primary interest include the growing adoption and emerging biological themes from single\u2010cell assays and analyses, the shift from characterization toward functional single\u2010cell studies, and strategies to maximize clinically relevant insights from dense single\u2010cell and spatial datasets. Ancillary topics include the historical evolution of the single\u2010cell EBV field and end\u2010to\u2010end single\u2010cell sequencing workflows. Special attention is given to open questions in molecular mechanisms of EBV pathogenesis and how they might be resolved by future studies utilizing single\u2010cell techniques.<\/jats:p>","DOI":"10.1002\/jmv.70825","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:33:54Z","timestamp":1770298434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epstein\u2010Barr Virus Infection at Single\u2010Cell Resolution"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3362-1028","authenticated-orcid":false,"given":"Elliott D.","family":"SoRelle","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology University of Michigan Ann Arbor Michigan USA"},{"name":"Department of Biological Chemistry University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"\u201cZen, or the Skill to Catch a Killer\u201d, Twin Peaks, Season","author":"Lynch D.","year":"1990"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92354-2"},{"key":"e_1_2_8_4_1","first-page":"2603","volume-title":"Epstein\u2010Barr Virus and Its Replication","author":"Kieff E. R.","year":"2007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80622-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00615-w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-023-00580-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1315"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12172"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4380"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14590"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0567-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2938"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3383"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12593"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2642"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-019-0116-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62586"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.1.45"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00049-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02609-08"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1001145"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010453"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28362"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/mra.00342-23"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111286"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112958"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02458"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102227"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008523117"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8222"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04432-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173489"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09378-0"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59813-z"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2426339122"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012341"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.03.025"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00091-7"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611128104"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114743"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46339"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-55928-5"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009041"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-025-03341-z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01051-24"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-19-0680"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110713"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-212098"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2025.111309"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303913"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70094"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0374-x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00402-8"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.02.010"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21795-z"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21043-4"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011934"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320368"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01622-1"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.188543"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adl3604"},{"key":"e_1_2_8_65_1","unstructured":"M.Cortese A.Ascherio andK.Bjornevik(Springer 2025)."},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105509"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead673"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ady0210"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49186-0"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03692-w"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60276-5"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-024-01701-0"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021074"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62090-5"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70491"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08697-6"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.13.5810-5818.2000"},{"key":"e_1_2_8_78_1","article-title":"Same\u2010Slide Spatial Multi\u2010Omics Integration Reveals Tumor Virus\u2010Linked Spatial Reorganization of the Tumor Microenvironment","volume":"1","author":"Yeo Y. Y.","year":"2024","journal-title":"bioRxiv"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00410-x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.15.682084"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.113626"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52153-4"},{"key":"e_1_2_8_83_1","article-title":"The Spatial Landscape of Infectious Mononucleosis Tonsils","volume":"1","author":"Leahy C. I.","year":"2025","journal-title":"bioRxiv"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00713"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004656"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200366597"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011939"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.04.005"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105822118"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1315"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:40:54Z","timestamp":1785519654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jmv.70825"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70825","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70825"}}