{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:05:29Z","timestamp":1785524729817,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study investigated the humoral immune response dynamics in patients with severe fever with thrombocytopenia syndrome (SFTS) to evaluate their prognostic value and construct an early warning model. A retrospective cohort of 36 laboratory\u2010confirmed SFTS patients with \u2265\u20094 serial antibody measurements out of 153 patients recruited in the study were analyzed. Patients were categorized by outcome into mild, severe, and fatal groups. The results showed that, the fatal group was older, had more comorbidities, and showed no antibody seroconversion during follow\u2010up, along with a significantly higher day\u20107 viral load. Early seroconversion (IgM\/IgG \u2264\u20097 days post\u2010admission) was associated with shorter recovery time and higher survival compared to delayed seroconversion (&gt;\u20097 days) or antibody\u2010deficient status. Antibody seroconversion time was strongly positively correlated with recovery time. Advanced age (\u2265\u200970 years) was a significant risk factor for severe\/fatal outcomes and was linked to delayed or absent seroconversion. A synergistic interaction was found between age and day\u20107 antibody status. A simple early warning model combining age and day\u20107 antibody status demonstrated good predictive performance with an AUC of 0.83. The findings indicate that antibody response timing and advanced age are key prognostic factors in SFTS. The proposed model shows promise for early identification of high\u2010risk patients in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/jmv.70830","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:27:22Z","timestamp":1770211642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibody Response Dynamics as an Early Predictor of Clinical Outcome in Severe Fever With Thrombocytopenia Syndrome (SFTS): A Retrospective Cohort Study for Prognostic Model Development"],"prefix":"10.1002","volume":"98","author":[{"given":"Rong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Virology Testing Disease Prevention and Control Center of Ningbo City Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Prevention and 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