{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:05:41Z","timestamp":1785524741789,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The factors involved in the development of functional dependence, pain and HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) could be linked to inflammatory cytokines and proviral load. This study aimed to assess the association between myelopathy, pain, and functionality with proviral load in blood, serum levels of cytokines and the interleukin 6 (IL\u20106) polymorphism in individuals living with HTLV\u20101. This was a cross\u2010sectional study. Consecutive HTLV\u20101\u2010infected patients, with or without HAM\/TSP, attending the infectious diseases clinic were included. A semi\u2010structured questionnaire, functional independence measure, and the numerical rating scale for pain intensity were applied and peripheral blood samples were collected. Plasma cytokines were determined by flow cytometry. Genotyping for the IL\u20106 gene polymorphism rs2069849 (A\u2009&gt;\u2009G) was performed using a TaqMan allelic discrimination assay. The proviral load was determined by Real\u2010time polymerase chain reaction. 165 patients were included, 72% women (aged 52\u2009\u00b1\u200913.1 years), 23% were functionally dependent, and 21% had HAM\/TSP. Patients functionally dependent had higher IL\u20106 and IL\u20108 levels and lower IL\u201010 levels. HAM\/TSP patients also showed higher IL\u20106 and IL\u20108. No associations were observed between any cytokine and chronic pain, pain frequency or intensity. Neither IL\u20106 polymorphism nor proviral load showed any association with myelopathy, pain, or functionality.<\/jats:p>","DOI":"10.1002\/jmv.70839","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:04:47Z","timestamp":1770901487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Association of Cytokines, Interleukin 6 Polymorphism, and Proviral Load With Myelopathy, Pain, and Functionality in HTLV1\u2010Infected Patients"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-1014","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Bastos Ferreira","sequence":"first","affiliation":[{"name":"Postgraduate Program in Neuropsychiatry and Behavioral Sciences (Posneuro) Universidade Federal de Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Machado Ribeiro Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Oswaldo Cruz (HUOC) Universidade de Pernambuco (UPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taciana","family":"Furtado de Mendon\u00e7a Belmont","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas (FCM) Universidade de Pernambuco (UPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice","family":"Neuenschwander Lins de Morais","sequence":"additional","affiliation":[{"name":"Departamento de Virologia Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luydson Richardson","family":"Silva Vasconcelos","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Instituto Aggeu Magalh\u00e3es Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Muniz Mendes Freire de Moura","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas (ICB) Universidade de Pernambuco (UPE) Recife Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-2637","authenticated-orcid":false,"given":"Pedro Augusto","family":"Sampaio Rocha\u2010Filho","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Oswaldo Cruz (HUOC) Universidade de Pernambuco (UPE) Recife Brazil"},{"name":"Division of Neuropsychiatry, Centro de Ci\u00eancias M\u00e9dicas Universidade Federal de Pernambuco (UFPE) Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2015.12"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2012.00389"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.966690"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13365-020-00832-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13365-018-0632-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMV.23341"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/510679"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13365-020-00914-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000866"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0006720"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.09.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/804167"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMV.21341"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00419-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199401000-00009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2006000200009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0152557"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2016.08.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/PM\/PNAE034"},{"key":"e_1_2_9_21_1","unstructured":"World Health Organization. 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