{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:04:49Z","timestamp":1785524689757,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      High\u2010dose Vitamin C (VitC) substantially boosts the anti\u2010tumor effect of oncolytic adenoviruses (oAds), but optimizing its therapeutic potential remains to be fully explored. This study aims to investigate the synergistic effects of VitC and oAds on tumor cell viability and the underlying mechanisms. The CCK\u20108 assay and Flow cytometry were employed to detect the viability and apoptosis of tumor cells treated with VitC, oAds and VitC plus oAds. The combination therapy increased the oncolytic effect by 25\u2010fold in CT26 cells and 10\u2010fold in 4T1 cells, highlighting that VitC could enhance the oncolytic effect of oAds. Intermittent injection of VitC, rather than continuous injection, combined with oAds, was applied to examine the anti\u2010tumor effect in vivo. Tumor\u2010bearing mice receiving intermittent VitC alongside oAds showed smaller tumor volume, tumor weight and longer survival compared to those receiving the monotherapy. Additionally, no remarkable side effects were observed, as indicated by H&amp;E staining of vital organs. Mechanistically, VitC synergized with oAds to recruit CD8\n                      <jats:sup>+<\/jats:sup>\n                      effector T cells. These lymphocytes released IFN\u2010\u03b3, which reduced the expression of SLC7A11, a subunit of cystine\/glutamate antiporter, and ultimately triggered ferroptosis by the reduced GSH. In conclusion, our findings propose a novel administration strategy for VitC that effectively augments the oncolytic effect of oAds, thereby warranting further investigation into its potential clinical applications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.70844","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:21:41Z","timestamp":1771075301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological Vitamin C Plus Oncolytic Adenoviruses Orchestrate Immunogenic Tumor Ferroptosis"],"prefix":"10.1002","volume":"98","author":[{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of gastrointestinal surgery Peking University Cancer Hospital (Inner Mongolia Campus)\/Affiliated Cancer Hospital of Inner Mongolia Medical University Hohhot 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