{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:51:04Z","timestamp":1775904664068,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human Parechovirus A (PeV\u2010A) is a virus with near\u2010universal infection by age five; however, neonatal infections can lead to meningoencephalitis, sepsis, and death. Prior to the COVID\u201019 pandemic, PeV\u2010A showed biennial seasonality with late summer peaks, but multiple viruses have had shifted circulation post\u2010pandemic. PeV\u2010A is not universally included in neonatal sepsis testing; thus, the frequency and clinical spectrum of PeV\u2010A neonatal meningoencephalitis are not fully described. We sought to evaluate the epidemiology, seasonality, and clinical presentation of neonatal PeV\u2010A in the 2024 season. We collected remnant cerebrospinal fluid samples from febrile infants under 60 days at a single children's hospital in Southwestern Pennsylvania and assessed for PeV\u2010A and enterovirus (EV). Six out of 107 (5.6%) febrile infants were positive for PeV\u2010A and 24 (22.4%) were positive for EV. PeV\u2010A infections occurred from June to September. PeV\u2010A positive patients had a distinct combination of higher maximum temperature, rash, and leukopenia without pleocytosis. None of these infants had severe disease. Systematic surveillance of PeV\u2010A is required to completely understand ongoing PeV\u2010A circulation patterns, expected clinical course, and long\u2010term developmental implications.<\/jats:p>","DOI":"10.1002\/jmv.70870","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:27:27Z","timestamp":1773224847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal CNS Human Parechovirus Infections in Western Pennsylvania in the 2024 Season"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0712-9761","authenticated-orcid":false,"given":"Gal","family":"Yovel","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica 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