{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:07:04Z","timestamp":1792465624876,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Patients with chronic inflammatory skin diseases (CISDs) are at an elevated risk for herpes zoster (HZ) and its complications. Therefore, effective prevention strategies are crucial for this high\u2010risk population. This study aimed to compare the vaccine effectiveness of recombinant zoster vaccine (RZV) versus live attenuated vaccine (LAV) in patients with CISDs. A retrospective cohort study was performed using data from the U.S. Collaborative Network of TriNetX. Adults aged \u2265\u200918 years with CISDs between 2014 and 2020 were included. The primary outcome was incident HZ; secondary outcomes included ophthalmic zoster (OZ), postherpetic neuralgia (PHN), and complicated HZ. Propensity score matching was performed for head\u2010to\u2010head comparisons, and Cox proportional hazards models were used to estimate hazard ratios (HRs). Compared with LAV, patients receiving RZV had a significantly lower risk of HZ (two\u2010dose RZV: HR 0.61; 95% CI, 0.54\u20130.69; one\u2010dose RZV: HR 0.65; 95% CI, 0.58\u20130.75). RZV was also associated with reduced risks of OZ, PHN, and complicated HZ. Subgroup analyses showed consistent risk reduction across patients with psoriasis, atopic dermatitis, hidradenitis suppurativa, vitiligo, and pemphigoid, as well as among adults aged \u2265\u200965 years. RZV is more effective than LAV in preventing HZ and its complications such as ophthalmic zoster and postherpetic neuralgia among patients with CISDs. These findings provide real\u2010world evidence that prioritize RZV use in this population.<\/jats:p>","DOI":"10.1002\/jmv.70893","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:31:58Z","timestamp":1774877518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Effectiveness of Recombinant Zoster and Live Attenuated Zoster Vaccines in Chronic Inflammatory Skin Diseases: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6887-5743","authenticated-orcid":false,"given":"Cheryl","family":"Lee","sequence":"first","affiliation":[{"name":"Rice University Houston Texas USA"},{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-5083","authenticated-orcid":false,"given":"Sheng\u2010Hsiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Public Health and Department of Public Health National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Fan","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Dermatology National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Dermatology National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-8114","authenticated-orcid":false,"given":"Tai\u2010Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw296"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1090"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.073"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.16"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab125"},{"key":"e_1_2_9_7_1","unstructured":"TriNetX [Internet] \u201cReal\u2010world Data for the Life Sciences and Healthcare \u201d [cited 2025 Jan] 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