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SARS\u2010CoV\u20102 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes. In this study, we demonstrated that the open reading frame 7b (ORF7b) accessory protein of SARS\u2010CoV\u20102 induces the NLRP3 inflammasome in a recombinant HEK293T model. This resulted in an increase in the distribution of NLRP3 puncta, ASC\u2010specking cells, and caspase\u20101 activation. ORF7b expression also induced the dispersion of the trans\u2010Golgi network, a well\u2010known step in the activation of the NLRP3 inflammasome. This study proposes a novel additional mechanism by which SARS\u2010CoV\u20102 promotes NLRP3 inflammasome activation by ORF7b.<\/jats:p>","DOI":"10.1002\/jmv.70894","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:45:14Z","timestamp":1774611914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Open Reading Frame 7b of the SARS\u2010CoV\u20102 Disperse Trans\u2010Golgi and Activate the NLRP3 Inflammasome"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-5896","authenticated-orcid":false,"given":"Julio","family":"Garc\u00eda\u2010Villalba","sequence":"first","affiliation":[{"name":"Biomedical Research Institute of Murcia (IMIB) University Clinical Hospital Virgen Arrixaca Murcia 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