{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:08:31Z","timestamp":1779368911419,"version":"3.53.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Squamous cell carcinoma of the anus (SCCA), caused by high\u2010risk human papillomavirus (HR\u2010HPV) genotypes, is a growing concern among gay, bisexual, and other men who have sex with men and transgender individuals, particularly those living with HIV. Early detection of precursor lesions is crucial, yet current screening methods face barriers in access and acceptability. Anal self\u2010sampling has emerged as a promising patient\u2010centered alternative. This study evaluates the diagnostic accuracy and feasibility of self\u2010collected anal swabs for HPV genotyping compared to clinician\u2010collected swabs among the target population. A cross\u2010sectional, multicenter study was conducted in the metropolitan area of Barcelona, enrolling 151 participants. Participants provided self\u2010 and clinician\u2010collected anal samples, obtained sequentially. Extended genotyping was performed to detect 28 individual HPV genotypes. Diagnostic performance was evaluated using clinician\u2010collected samples as the reference standard, and concordance was assessed using McNemar's test and Cohen's \u03ba statistic. Feasibility was measured via a questionnaire. Participants had a median age of 43 years, and 53.0% were living with HIV. Overall, HPV was detected in 89.9% of self\u2010 and 92.6% of clinician\u2010collected samples. Agreement was high 96.0%, with a \u03ba value of 0.75 (95% CI: 0.55\u20130.94). No significant differences were found between methods (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.22). Sensitivity was 96.4% (95% CI: 91.8\u201398.4), and specificity 90.9% (95% CI: 62.3\u201398.4), with similar accuracy for HR\u2010HPV and HPV16 types. Most participants rated self\u2010sampling acceptable and feasible. Anal self\u2010sampling shows high accuracy and strong feasibility, supporting its use as a viable and user\u2010friendly strategy to enhance HPV screening in key populations at risk for SCCA.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70908","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:22:49Z","timestamp":1775654569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concordance and Acceptability of Self\u2010 Vs. Clinician\u2010Collected Anorectal Swabs for HPV Genotyping in Gay, Bisexual and Other Men Who Have Sex With Men in Metropolitan Barcelona"],"prefix":"10.1002","volume":"98","author":[{"given":"Leila","family":"Ferrera","sequence":"first","affiliation":[{"name":"Centre of Epidemiological Studies on Sexually Transmitted Infections and AIDS of Catalonia (CEEISCAT). The Ministry of Health Government of Catalonia Badalona Spain"},{"name":"School of Public Health Pasteur\u2010Cnam Paris France"},{"name":"Germans Trias i Pujol Research Institute (IGTP) Campus Can Ruti Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Mart\u00ednez\u2010Riveros","sequence":"additional","affiliation":[{"name":"Centre of Epidemiological Studies on Sexually Transmitted Infections and AIDS of Catalonia (CEEISCAT). The Ministry of Health Government of Catalonia Badalona Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP) Campus Can Ruti Badalona Spain"},{"name":"Department of Paediatrics, Obstetrics and Gynecology and Preventive Medicine Univ Autonoma de Barcelona  Spain"},{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Sa\u00f1a","sequence":"additional","affiliation":[{"name":"Centre of Epidemiological Studies on Sexually Transmitted Infections and AIDS of Catalonia (CEEISCAT). The Ministry of Health Government of Catalonia Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-7092","authenticated-orcid":false,"given":"Sara","family":"Tous","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"},{"name":"Unit of Molecular Epidemiology and Genetics (UNIC EMG). Cancer Epidemiology Research Programme Catalan Institute of Oncology (ICO)\u2010 IDIBELL, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Vega","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, HIV and STD Unit (Infectious Disease Service), L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sanchez\u2010Llamas","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, HIV and STD Unit (Infectious Disease Service), L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Sirera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Fight AIDS Foundation Hospital Germans Trias Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge N\u00e9stor","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Vall d'Hebron\u2010Drassanes STI and HIV Unit Hospital Universitario Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Esteban","sequence":"additional","affiliation":[{"name":"Infections and Cancer Laboratory, Cancer Epidemiology Research Programme Catalan Institute of Oncology (ICO)\u2010 IDIBELL, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel \u00c0ngel","family":"Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"},{"name":"Infections and Cancer Laboratory, Cancer Epidemiology Research Programme Catalan Institute of Oncology (ICO)\u2010 IDIBELL, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Alemany","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"},{"name":"Unit of Molecular Epidemiology and Genetics (UNIC EMG). Cancer Epidemiology Research Programme Catalan Institute of Oncology (ICO)\u2010 IDIBELL, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-2242","authenticated-orcid":false,"given":"Cristina","family":"Agust\u00ed","sequence":"additional","affiliation":[{"name":"Centre of Epidemiological Studies on Sexually Transmitted Infections and AIDS of Catalonia (CEEISCAT). The Ministry of Health Government of Catalonia Badalona Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP) Campus Can Ruti Badalona Spain"},{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f2nia","family":"Paytubi","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain"},{"name":"Infections and Cancer Laboratory, Cancer Epidemiology Research Programme Catalan Institute of Oncology (ICO)\u2010 IDIBELL, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33185"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34269"},{"issue":"7","key":"e_1_2_10_4_1","first-page":"1017","article-title":"Cervical Cancer: Epidemiology, Prevention and the Role of Human Papillomavirus Infection","volume":"164","author":"Franco E. 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