{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:05:28Z","timestamp":1784430328116,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colorectal and cervical cancers represent an important public health problem worldwide, particularly in Brazil. Colorectal cancer is one of the most frequently diagnosed malignancies worldwide and the most common cancer in both men and woman in Brazil. Although cervical cancer also remains a significant public health concern in the female population due to its high incidence and mortality rates. Epstein\u2010Barr virus (EBV), and Polyomaviruses (JCPyV and BKPyV) are considered as oncoviruses with a prevalence of 90% in the adult population. Studies suggest that coinfection with Human papillomavirus (HPV) and EBV, JCPyV and BKPyV can be associated with anal cancer, with HPV being the dominant viral cause. Although in cervical cancer, this coinfection is often observed, and it may enhance cervical oncogenic potential. These facts are particularly concerning in women living with HIV, who are more susceptible to persistent HPV infections and HPV\u2010related cancers. This study aimed to investigate EBV, JCPyV and BKPyV presence in HPV\u2010infected women living with HIV. This cross\u2010sectional study collected 33 cervical and 30 anal scrapings samples, as well as 26 paired samples from both sites from HPV\u2010positive women living with HIV. Viral detection and quantification for EBV, JCPyV and BKPyV were performed using real\u2010time polymerase chain reaction (qPCR), while HPV detection and genotyping utilized the Novaplex\n                    <jats:sup>TM<\/jats:sup>\n                    assay. EBV was detected in 33.3% of anal scraping and 21.2% in cervical scraping. HPV 51 and HPV 56 were most frequently detected in anal and cervical scrapings, respectively. The EBV mean viral load was higher in cervical scraping (2.27\u2009\u00d7\u200910^5 copies\/mL) when compared to anal scraping (1.19\u2009\u00d7\u200910^5 copies\/mL) in relation of JCPyV and BKPyV viral loads. Regarding coinfections, it was found that EBV presented a high coinfection rate with high\u2010risk HPV genotypes (hrHPV) (14.6%) with HPV 31 in both samples. This study provided valuable data about the frequency of EBV in anal and cervical HPV\u2010positive women. The elevated viral load of EBV in cervical scrapings may suggest a potential role in modulating the local microenvironment and warrants further investigation into the synergistic effects of EBV and HPV in anogenital and cervical carcinogenesis. Overall, the results of this study emphasize the need for further investigation into the role of these viruses in the progression of cervical lesions.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70909","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:15:49Z","timestamp":1776345349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond Human Papillomavirus (HPV): Detection of EBV and Polyomaviruses in Cervical and Anal Samples"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-9156","authenticated-orcid":false,"given":"Ana Carolina Silva","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory Oswaldo Cruz Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-7689","authenticated-orcid":false,"given":"Luana L. S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory\u2014Institute of Collective Health Federal University of Western Par\u00e1 Par\u00e1 Brazil"},{"name":"Graduate Program in Health Sciences\u2014Institute of Collective Health Federal University of Western Par\u00e1 Para Brazil"},{"name":"Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7236-8602","authenticated-orcid":false,"given":"Let\u00edcia Bomfim","family":"Campos","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory Oswaldo Cruz Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-3241","authenticated-orcid":false,"given":"Katrini G.","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Collective Health Federal University of Esp\u00edrito Santo Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-0022","authenticated-orcid":false,"given":"Nath\u00e1lia Silva Carlos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pathology\u2014School of Medicine Fluminense Federal University Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-3159","authenticated-orcid":false,"given":"W. Martin","family":"Kast","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Southern California Los Angeles USA"},{"name":"Norris Comprehensive Cancer Center University of Southern California Los Angeles USA"},{"name":"Department of Molecular Microbiology and Immunology University of Southern California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Gaydos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Johns Hopkins University, School of Medicine Baltimore USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Silva","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-8597","authenticated-orcid":false,"given":"Jos\u00e9 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