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While vaccines are effective in preventing new infections, they do not address existing cases, highlighting the need for innovative therapies. Gene\u2010targeted approaches, such as CRISPR\/Cas and siRNA, show promise in inhibiting HPV oncogenes. Recent advancements in Trojan horse nanoparticles (NPs) offer a strategy for delivering these therapies directly to HPV\u2010infected cells. These NPs improve stability and targeted delivery, enhancing the biodistribution of CRISPR\/Cas systems and siRNAs while protecting them from degradation. However, challenges like immune responses and regulatory hurdles persist. 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