{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:08:31Z","timestamp":1779368911565,"version":"3.53.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cervical cancer exerts a significant public health burden globally and in India. While HPV\u201016 and HPV\u201018 are well\u2010known etiological agents, emerging evidence highlights the regional significance of other high\u2010risk genotypes like HPV\u201058 and HPV\u201059. This study aimed to evaluate the prevalence and cytological associations of HPV genotypes, particularly 58 and 59, in Northeast Indian women. A total of 429 cervical swab specimens were collected from women attending the routine outpatient department at NEIGRIHMS, Shillong, between 2021 and 2025, following informed consent and institutional ethical approval. Cytological analysis and demographic data collection were performed. HPV genotyping was carried out at the reference lab at Pune using the Xpert HPV assay and qPCR Panel. Among 429 participants, 74 (17.25%) tested positive for HPV. Among the HPV positive cases, the genotype distribution was: HPV\u201016 (52.70%), HPV\u201018 (8.10%), and HPV\u201058(5.40%) and HPV\u201059 (13.51%). Notably, HPV\u201058 positive women exhibited abnormal cytology, while HPV\u201059 positive patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), Pap smears showed NILM (6), ASC\u2010US (1), Bacterial vaginosis (2), and One case of Poorly Differentiated Malignancy. This study underscores the emerging clinical relevance of HPV\u201058 and 59 in Northeast India. The higher cytological abnormality in HPV\u201058 cases highlights the need for expanded HPV genotyping in screening programs.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70924","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:04:59Z","timestamp":1775901899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond HPV\u201016 and 18: Clinical Significance of HPV\u201058 and 59 in Cervical Abnormalities in Northeast India"],"prefix":"10.1002","volume":"98","author":[{"given":"Vishal","family":"Koligudde","sequence":"first","affiliation":[{"name":"ICMR\u2010National Institute of Virology, Pune, Maharashtra, India Academy of Scientific and Innovative Research (AcSIR) Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manika","family":"Agarwal","sequence":"additional","affiliation":[{"name":"North Eastern Indira Gandhi Regional Institute of Health &amp; Medical Sciences Shillong Meghalaya India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evarisalin","family":"Marbaniang","sequence":"additional","affiliation":[{"name":"North Eastern Indira Gandhi Regional Institute of Health &amp; Medical Sciences Shillong Meghalaya India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Shinde","sequence":"additional","affiliation":[{"name":"ICMR\u2010National Institute of Virology Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-9313","authenticated-orcid":false,"given":"Mallika","family":"Lavania","sequence":"additional","affiliation":[{"name":"ICMR\u2010National Institute of Virology, Pune, Maharashtra, India Academy of Scientific and Innovative Research (AcSIR) Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.11.046"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.111"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.033"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 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