{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:08:46Z","timestamp":1779368926743,"version":"3.53.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSC 113\u20102314\u2010B\u2010002\u2010123"],"award-info":[{"award-number":["NSC 113\u20102314\u2010B\u2010002\u2010123"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114\u20102314\u2010B\u2010002\u2010182 and 114\u20102327\u2010B\u201000"],"award-info":[{"award-number":["114\u20102314\u2010B\u2010002\u2010182 and 114\u20102327\u2010B\u201000"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Enteroviruses (EVs) cause a wide range of pediatric illnesses. In Taiwan, changes in serotype distribution and COVID\u201019\u2010related public health measures may have influenced recent EV trends. We retrospectively reviewed EV\u2010positive pediatric inpatients (&lt;\u200918 years) at National Taiwan University Hospital from 2015 to 2023. Cases were identified via PCR or viral culture. Among 678 cases, incidence declined markedly during the COVID\u201019 period but rebounded after public health restrictions were relaxed, with seasonal peaks in June persisting. Echovirus 11 emerged as the predominant serotype among neonatal cases (23.1%) and severe cases (9.5%), whereas EV\u2010A71 was mainly associated with hand\u2010foot\u2010mouth disease. Severe cases were significantly younger (median 0.8 vs. 1.5 years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and more likely to have underlying conditions, including congenital syndromes and cardiovascular diseases. The only mortality occurred in a neonate with echovirus 11 infection. Viral or bacterial co\u2010detections were not associated with severity. Echovirus 11 has replaced EV\u2010A71 as a leading cause of severe and neonatal EV infections in Taiwan. Younger age and underlying conditions were significant risk factors for severe disease. Ongoing surveillance and vaccine development should prioritize currently circulating virulent serotypes and high\u2010risk pediatric populations.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70929","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:39:22Z","timestamp":1776692362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of Echovirus 11 in Severe and Neonatal Enterovirus Infections: A 9\u2010Year Retrospective Study in Taiwan Before and After the COVID\u201019 Pandemic"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2959-058X","authenticated-orcid":false,"given":"Sheng\u2010Yuan","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-5664","authenticated-orcid":false,"given":"Yun\u2010Chung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei Taiwan"},{"name":"Department of Biomedical Informatics and Data Science Johns Hopkins School of Medicine, Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Yuan","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-9279","authenticated-orcid":false,"given":"Shun\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology College of Medicine, National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yi","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan\u2010Yin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University Taipei Taiwan"},{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"W.SinclairandM.OmarEnterovirus. 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