{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:08:31Z","timestamp":1779368911503,"version":"3.53.0"},"reference-count":106,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe COVID\u201019 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID\u201019. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA\u2010seq samples, and over 2 million single cells. A vote\u2010counting strategy combined with a systems\u2010biology approach was applied to detect consensus differentially expressed genes (DEGs). Pathways related to interferon\/TNF\u2010\u03b1 signaling, hypoxia response, and platelet activation were consistently enriched across data sets. Among consensus DEGs\u2014such as IFITM3, BCL2A1, CAMK2D, and CCR1\u2014RAB8B was prioritized for functional validation based on its recurrence in ~45% of tissues and its known role in vesicle trafficking, a process intimately linked to viral life cycles. Molecular dynamics simulations and in vitro assays in SARS\u2010CoV\u20102\u2010infected CaCo\u20102 cells demonstrated that RAB8B modulates VAMP\u20103 clustering and intracellular trafficking. Silencing of Rab8b\u20101 and Rab8b\u20102 reduced viral infection by 30% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0302) and 76% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), respectively. This study defines robust consensus signatures and positions RAB8B as a critical host factor and potential therapeutic target in severe COVID\u201019. Further exploration of RAB8B inhibitors is warranted to explore therapeutic utility. An interactive database at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/covidatlas.sysbio.tools\/\">https:\/\/covidatlas.sysbio.tools\/<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/jmv.70932","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:50:51Z","timestamp":1776833451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiorgan Molecular Landscape of Severe COVID\u201019 Revealed by Consensus Gene Signatures and RAB8B Targeting"],"prefix":"10.1002","volume":"98","author":[{"given":"Jonathan Pe\u00f1a","family":"Avila","sequence":"first","affiliation":[{"name":"Department of Clinical and Toxicological Analyses University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Institut Pasteur de S\u00e3o Paulo University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youvika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Parasitology Leiden University Center for Infectious Diseases (LU\u2010CID), Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo P.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Instituto de Ensino e Pesquisa, Insper S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdcaro","family":"Castro","sequence":"additional","affiliation":[{"name":"Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ten\u2010Caten","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases University of S\u00e3o Paulo Medical School, University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 N. 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