{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:01:00Z","timestamp":1791381660363,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["10\u2010001896"],"award-info":[{"award-number":["10\u2010001896"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["17\u20100185"],"award-info":[{"award-number":["17\u20100185"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Studies have shown that Torque teno virus (TTV) viral load predicts antibody response to SARS\u2010CoV\u20102 mRNA vaccines in kidney transplant recipients (KTRs). However, its correlation with pneumococcal vaccine antibody response remains unknown. We enrolled KTRs receiving the 13\u2010valent pneumococcal conjugate vaccine (PCV13). TTV viral load and 12 pneumococcal serotype\u2010specific (PSS) IgG antibodies were measured at baseline. PSS IgG antibodies again 12 weeks post\u2010vaccination. Vaccine responders were defined as those with a minimum two\u2010fold increase in the geometric mean concentration across all 12 PSS IgG antibodies. Logistic regression was used to identify predictors of vaccine response, and receiver operating characteristic curve analysis assessed the diagnostic performance of TTV viral load. Among 65 vaccinated KTRs, 38% responded to the vaccine. TTV viral load was inversely associated with vaccine response (adjusted odds ratio: 0.64, 95% CI: 0.46\u20130.88,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006); no other variables were significantly associated. TTV viral load demonstrated modest diagnostic utility, with an area under the curve of 0.74 (95% CI: 0.61\u20130.84) and an optimal threshold of 4.71\u2009log\u2081\u2080 copies\/mL (sensitivity 60%, specificity 85%). These findings suggest that TTV viral load may serve as a predictor of PCV13 vaccine responsiveness and could help optimize immunization strategies in KTRs.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70949","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:56:50Z","timestamp":1777276610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Torque Teno Virus Viral Load as a Predictive Marker of Serotype\u2010Specific Antibody Response Following the 13\u2010Valent Conjugated Pneumococcal Vaccine in Adult Kidney Transplant Recipients: A Cohort Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-4182","authenticated-orcid":false,"given":"Lykke","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"Research Unit of Infectious Diseases 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Sv\u00e6rke","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Virus and Microbiological Preparedness Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-6595","authenticated-orcid":false,"given":"Christian","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-4711","authenticated-orcid":false,"given":"Silje Vermedal","family":"Hoegh","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-055X","authenticated-orcid":false,"given":"Rune 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