{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:00:57Z","timestamp":1791381657481,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000951","name":"Cancer Council Victoria","doi-asserted-by":"publisher","award":["APP1130507"],"award-info":[{"award-number":["APP1130507"]}],"id":[{"id":"10.13039\/501100000951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1197951"],"award-info":[{"award-number":["APP1197951"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Anal cancer, caused by persistent infection with oncogenic human papillomavirus (HPV), is rare in the general population. However, certain groups, such as men who have sex with men living with HIV, are at much higher risk, and research into the etiology and pathogenesis of the disease has focused on this group. Other high\u2010risk groups, such as women with a history of gynecological HPV\u2010related disease, have been neglected. While single anal cancer lesions typically contain one HPV genotype, multiple genotypes are often detected in anal swabs, complicating attribution. Identifying the causal genotype is essential to assessing the potential impacts of HPV vaccination programs. This study used laser capture microdissection (LCM) to identify the lesion\u2010specific HPV genotype in anal squamous cell carcinomas from women. Thirty\u2010five anal cancer samples from women were drawn from the Anal Cancer Outcomes Research Network \u2013 Baseline Study (ACORN). Five were excluded, leaving 30 specimens from cisgender women for analysis. p16 immunostaining confirmed high\u2010risk HPV infection; HPV genotyping using the HPV SPF10\u2010LiPA25 kit identified the causal genotype for each cancer. The median age at diagnosis was 58.5 (IQR 48\u201372). All specimens contained a single HPV genotype: 93.3% HPV16, 3.3% HPV18, and 3.3% HPV31. To our knowledge, this is the first study to use LCM on anal cancer biopsies from women to attribute a causal HPV genotype. All specimens tested positive for a single genotype, with HPV16 causing almost all cancers. All cases in this sample could potentially have been prevented by nonavalent prophylactic vaccination, and 97% by the quadrivalent vaccine.<\/jats:p>","DOI":"10.1002\/jmv.70957","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:48:41Z","timestamp":1778244521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causative Human Papillomavirus (HPV) Genotypes of Anal Cancers in Australian Cisgender Women"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-4029","authenticated-orcid":false,"given":"Clare E. 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Victoria Australia"},{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Comben","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-8475","authenticated-orcid":false,"given":"Alyssa M.","family":"Cornall","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital Parkville Victoria Australia"},{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L.","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious 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