{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:00:56Z","timestamp":1791381656229,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Since its emergence in 2019, severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) has caused a global pandemic driven by rapid mutation and high transmissibility. Current therapeutic strategies may not effectively address the continuously evolving mutant strains, underscoring the need for treatments with broad neutralizing activity. Two monoclonal antibodies (mAbs): SR\u201023 and CS\u201042, isolated from convalescent patients infected with SARS\u2010CoV\u20102 during the early phase of the 2020 pandemic, demonstrated significant neutralizing activities against a variety of variants. Specifically, SR\u201023 exhibited neutralizing activity against BA.5 and XBB1.5, whereas CS\u201042 showed efficacy against Delta, BA.1, and BA.2 variants. In addition, combining the two mAbs demonstrated improved neutralization activity. Cryo\u2010electron microscopy (cryo\u2010EM) structural analysis revealed that SR\u201023 and CS\u201042 bind to nonoverlapping epitopes on the SARS\u2010CoV\u20102 spike protein. Furthermore, both antibodies exhibited strong therapeutic effects in K18\u2010hACE2 mice infected with D614G, BA.2, and XBB.1.5. These findings provide insights into the development of antibody\u2010based therapeutics targeting emerging Omicron variants and suggest that combined administration could broaden neutralizing activity.<\/jats:p>","DOI":"10.1002\/jmv.70969","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:44:32Z","timestamp":1778676272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Broad Neutralizing Activity of Monoclonal Antibodies Against the Omicron Variants Isolated From Patients With Early Severe Acute Respiratory Syndrome Coronavirus\u20102"],"prefix":"10.1002","volume":"98","author":[{"given":"Da Sol","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Emerging Virus and Vector Research, Center for Emerging Virus Research, Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju\u2010si Republic of 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