{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:01:01Z","timestamp":1791381661017,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Schistosomiasis ranks as the second most significant parasitic illness in terms of socioeconomic impact, after malaria. The hepatitis C virus (HCV) is a primary cause of serious liver disease, such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Schistosomiasis increases the probability of HCV co\u2010infection, exacerbates liver damage, and reduces the efficacy of antiviral treatments. The study aimed to compare the prognostic significance of serologically identified versus biopsy\u2010confirmed hepatic schistosomiasis (bilharzial hepatic granuloma) in chronic HCV patients treated with interferon\u2010based therapy. A cohort of 453 patients with chronic HCV who received interferon\u2010based therapy was followed over 12 years. Baseline assessments included clinical and laboratory tests, transient elastography, indirect hemagglutination assay (IHA) for Schistosoma antibodies, and liver biopsy. Outcomes were monitored through periodic clinical, laboratory, and elastography evaluations. fibrosis progression occurred in 50% (4\/8) of patients with hepatic granulomas, while 50% demonstrated a stable course; no regression was observed. Fibrosis outcomes did not differ significantly between patients with low versus high indirect hemagglutination assay (IHA) titers. No mortality or episodes of hepatic decompensation were recorded in either group. Notably, HCC developed exclusively in the high IHA titer group (incidence rate: 0.08 per 100 person\u2010years). Liver Biopsy\u2010confirmed schistosomiasis granuloma exacerbates fibrosis outcomes in interferon\u2010treated chronic HCV patients. Additionally, a high Schistosoma antibody titer (IHA) is linked to increased HCC incidence, underscoring the prognostic value of both biopsy and serologic evaluation in this population.<\/jats:p>","DOI":"10.1002\/jmv.70974","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:09:52Z","timestamp":1779196192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Schistosomiasis on Fibrosis Evolution After Interferon\u2010Induced SVR in Chronic HCV Over a 12\u2010Year Biopsy\u2010Based Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-7398","authenticated-orcid":false,"given":"Mohamed","family":"Elbasiony","sequence":"first","affiliation":[{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH) Mansoura Egypt"},{"name":"Hepatology and Gastroenterology Unit, Internal Medicine Department Faculty of Medicine, Mansoura 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