{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:00:59Z","timestamp":1791381659754,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270596"],"award-info":[{"award-number":["82270596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis E virus (HEV) is one of the most prevalent causes underlying acute hepatitis and jaundice worldwide. This study aimed to describe and analyze the correlations between serum lipids, apolipoproteins and outcomes of acute hepatitis E and to explore serum lipid metabolism markers for severe clinical phenotypes of HEV infection. A total of 496 adult HEV\u2010infected patients were enrolled in this study, and their clinical and biochemical parameters were collected. The associations of serum lipids and apolipoproteins with the prognosis of the disease were described and compared. Additionally, the predictive value of apolipoprotein A\u2010I (apoA\u2010I) for the risks of severe jaundice, liver failure and mortality was analyzed. ApoA\u2010I showed a close association with the disease severity of acute hepatitis E, and the baseline apoA\u2010I level could serve as a predictive index for severe jaundice, liver failure and mortality. Using the cutoff values of 0.675\u2009g\/L and 0.435\u2009g\/L, patients could be stratified into corresponding risk groups for severe jaundice and mortality, respectively. This study revealed that serum apoA\u2010I level is a strong prognostic indicator for severe jaundice and mortality and it may serve as an effective biomarker for severe acute hepatitis E.<\/jats:p>","DOI":"10.1002\/jmv.70986","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:27:26Z","timestamp":1779539246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Apolipoprotein A\u2010I in Acute Hepatitis E Virus (HEV) Infection: A Single\u2010Center, Retrospective, Cohort Study From Shanghai, China"],"prefix":"10.1002","volume":"98","author":[{"given":"Xu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson Medical School and Center for Advanced Biotechnology and Medicine Rutgers University Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhua","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-8803","authenticated-orcid":false,"given":"Qing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-8758","authenticated-orcid":false,"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v12.i5.262"},{"key":"e_1_2_10_3_1","article-title":"Cholestasis in Hepatitis E Virus Infection","volume":"17","author":"Kanda T.","year":"2025","journal-title":"World Journal of Hepatology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28436"},{"key":"e_1_2_10_5_1","first-page":"413","article-title":"A Nationwide Retrospective Study on Prevalence of Hepatitis E Virus Infection in Italian Blood Donors","volume":"16","author":"Spada E.","year":"2018","journal-title":"Blood Transfusion = Trasfusione del Sangue"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13030492"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01362.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2018.0146"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.04.022"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12530"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12846"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7279"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.026"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13885"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01826-y"},{"key":"e_1_2_10_16_1","first-page":"820","article-title":"[Consensus on Prevention and Treatment of Hepatitis E]","volume":"30","author":"Chinese Society of Hepatology C. 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